ReviewTrends in cell biology2008
AsSIRTing the DNA damage response.
Review in Trends in cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases.Cell stress & chaperones · 2024Review
- RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer.Advanced drug delivery reviews · 2022Review
- Peptide Hormone Regulation of DNA Damage Responses.Endocrine reviews · 2020Review
- Targeting Nuclear NADCancers · 2020Article
- Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates.Current genomics · 2019Review
- Review
- p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death.International journal of molecular sciences · 2019Review
- Article
- Epigenetic Targeting of Autophagy via HDAC Inhibition in Tumor Cells: Role of p53.International journal of molecular sciences · 2018Review
- Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR.Nucleic acids research · 2018Article
- Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction.International journal of molecular sciences · 2018Review
- Review
- Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer.Cancer discovery · 2017Article
- The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2.Journal of virology · 2017Article
- Insulin-Like Growth Factor-1-Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent.Journal of dental research · 2017Article
- HDACs and HDAC Inhibitors in Cancer Development and Therapy.Cold Spring Harbor perspectives in medicine · 2016Review
- SIRTain regulators of premature senescence and accelerated aging.Protein & cell · 2015Review
- Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival.The Journal of biological chemistry · 2015Article
- Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression.Journal of inflammation (London, England) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In mammalian cells, changes in signaling networks and expressed proteins ensure the adequate detection and management of damaged macromolecules. Here, we review an emergent pathway of maintenance of homeostasis following genotoxic stress. The RNA-binding protein HuR associates with sirtuin (SIRT)1 mRNA and maintains constitutively elevated levels of SIRT1 protein, a deacetylase that elicits a prosurvival function. SIRT1 was recently shown to deacetylate the Nijmegen breakage syndrome (NBS1) protein, thereby rendering it phosphorylatable by ataxia telangiectasia mutated protein (ATM). A component of the MRN (MRE11-RAD50-NBS1) nuclease complex, NBS1 is crucial for sensing DNA damage and mounting a genotoxic response. This article covers the regulatory pathway of HuR-->SIRT1-->NBS1, through which post-transcriptional and post-translational effectors contribute to the maintenance of genomic integrity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.