ArticleMolecular and cellular endocrinology2008
Differential modulation of glucocorticoid and progesterone receptor transactivation.
Article in Molecular and cellular endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Post-translational modifications of the progesterone receptors.The Journal of steroid biochemistry and molecular biology · 2014Review
- Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility.The Journal of biological chemistry · 2013Article
- PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.The Journal of biological chemistry · 2013Article
- Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation.The Journal of biological chemistry · 2012Article
- Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors.Biochemistry · 2011Article
- Inferring mechanisms from dose-response curves.Methods in enzymology · 2011Article
- Glucocorticoid receptor cofactors as therapeutic targets.Current opinion in pharmacology · 2010Review
- STAMP alters the growth of transformed and ovarian cancer cells.BMC cancer · 2010Article
- Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells.Human immunology · 2009Article
- Modulation of transcription parameters in glucocorticoid receptor-mediated repression.Molecular and cellular endocrinology · 2008Article
- What goes on behind closed doors: physiological versus pharmacological steroid hormone actions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The determinants of the different biological activities of progesterone receptors (PRs) vs. glucocorticoid receptors (GRs), which bind to the same DNA sequences, remain poorly understood. The mechanisms by which differential expression of a common target gene can be achieved by PR and GR include unequal agonist steroid concentrations for half maximal induction (EC50) and dissimilar amounts of residual partial agonist activity for antisteroids in addition to the more common changes in total gene induction, or Vmax. Several factors are known to alter some or all of these three parameters for GR-regulated gene induction and some (i.e., the corepressors NCoR and SMRT) modulate the EC50 and partial agonist activity for GR and PR induction of the same gene in opposite directions. The current study demonstrates that other factors known to modulate GR properties (GME, GMEB-2, Ubc9, and STAMP) can also differentially interact with PRs or alter several of the above induction parameters under otherwise identical conditions. These results support the hypothesis that the modulation of EC50, partial agonist activity, and Vmax by a given factor is not limited to one receptor in a specific cell line. Furthermore, the number of factors that unequally modulate PR and GR induction parameters is now greatly expanded, thereby increasing the possible mechanisms for differential gene regulation by PRs vs. GRs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.