ArticleRespiratory research2008
The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children.
Article in Respiratory research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Health care costs of influenza-related episodes in high income countries: A systematic review.PloS one · 2018Pooled it
- Pooled it
- Cost of management of severe pneumonia in young children: systematic analysis.Journal of global health · 2016Pooled it
- Feasibility of a hybrid clinical trial for respiratory virus detection in toddlers during the influenza season.BMC medical research methodology · 2021Trial
- The Respiratory Specimen Collection Trial (ReSpeCT): A Randomized Controlled Trial to Compare Quality and Timeliness of Respiratory Sample Collection in the Home by Parents and Healthcare Workers From Children Aged <2 Years.Journal of the Pediatric Infectious Diseases Society · 2020Trial
- Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial.European journal of clinical nutrition · 2016Trial
- The respiratory health of urban indigenous children aged less than 5 years: study protocol for a prospective cohort study.BMC pediatrics · 2015Trial
- Quality of life for parents of children with influenza-like illness: development and validation of Care-ILI-QoL.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014Trial
- DO IT Trial: vitamin D Outcomes and Interventions in Toddlers - a TARGet Kids! randomized controlled trial.BMC pediatrics · 2014Trial
- Safety and tolerability of a 2009 trivalent inactivated split-virion influenza vaccine in infants, children and adolescents.Influenza and other respiratory viruses · 2013Trial
- Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial.Influenza and other respiratory viruses · 2013Trial
- The epidemic trend of rhinovirus in children from 2013 to 2023: a large sample study in China.Italian journal of pediatrics · 2025Article
- Real World Evaluation of Next-Day Molecular Respiratory Infectious Disease Testing on Healthcare Resource Utilization and Costs.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Surveillance towards preventing paediatric incidence of respiratory syncytial virus attributable respiratory tract infection in primary and secondary/tertiary healthcare settings in Merseyside, Cheshire and Bristol, UK.BMJ open respiratory research · 2023Observational
- The Link between Different Types of Prebiotics in Infant Formula and Infection Rates: A Review.Nutrients · 2023Review
- XiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial viruses.Pharmaceutical biology · 2022Article
- Molecular epidemiology of Enteroviruses and Rhinoviruses in patients with acute respiratory infections in Yaounde, Cameroon.Influenza and other respiratory viruses · 2021Article
- Evaluation of a standardised protocol to measure the disease burden of respiratory syncytial virus infection in young children in primary care.BMC infectious diseases · 2021Article
- Cost of Illness in Young Children: A Prospective Birth Cohort Study.Children (Basel, Switzerland) · 2021Article
- Burden of disease in children with respiratory tract infections in primary care: diary-based cohort study.Family practice · 2019Observational
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory illnesses (ARIs) during childhood are often caused by respiratory viruses, result in significant morbidity, and have associated costs for families and society. Despite their ubiquity, there is a lack of interdisciplinary epidemiologic and economic research that has collected primary impact data, particularly associated with indirect costs, from families during ARIs in children.
methodsWe conducted a 12-month cohort study in 234 preschool children with impact diary recording and PCR testing of nose-throat swabs for viruses during an ARI. We used applied values to estimate a virus-specific mean cost of ARIs.
resultsImpact diaries were available for 72% (523/725) of community-managed illnesses between January 2003 and January 2004. The mean cost of ARIs was AU$309 (95% confidence interval $263 to $354). Influenza illnesses had a mean cost of $904, compared with RSV, $304, the next most expensive single-virus illness, although confidence intervals overlapped. Mean carer time away from usual activity per day was two hours for influenza ARIs and between 30 and 45 minutes for all other ARI categories.
conclusionFrom a societal perspective, community-managed ARIs are a significant cost burden on families and society. The point estimate of the mean cost of community-managed influenza illnesses in healthy preschool aged children is three times greater than those illnesses caused by RSV and other respiratory viruses. Indirect costs, particularly carer time away from usual activity, are the key cost drivers for ARIs in children. The use of parent-collected specimens may enhance ARI surveillance and reduce any potential Hawthorne effect caused by compliance with study procedures. These findings reinforce the need for further integrated epidemiologic and economic research of ARIs in children to allow for comprehensive cost-effectiveness assessments of preventive and therapeutic options.
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