ArticleBMC developmental biology2008
MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element.
Article in BMC developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Synergistic Enhancement of Facial Nerve Regeneration Using a Cellulose-Based Nerve Conduit Loaded with Mesenchymal Stem Cells and Human Placental Extract.Bioengineering (Basel, Switzerland) · 2026Article
- Notch, Numb and Numb-like responses to exercise-induced muscle damage in human skeletal muscle.Experimental physiology · 2022Article
- The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise.Frontiers in neuroscience · 2017Review
- Tissue-specific epigenetics in gene neighborhoods: myogenic transcription factor genes.Human molecular genetics · 2015Article
- Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation.Scientific reports · 2013Article
- GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.Cellular and molecular life sciences : CMLS · 2012Article
- Tissue-specific stem cells: lessons from the skeletal muscle satellite cell.Cell stem cell · 2012Review
- SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.PloS one · 2012Article
- Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish.Developmental biology · 2011Article
- Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice.EMBO molecular medicine · 2011Article
- Cdkn1c drives muscle differentiation through a positive feedback loop with Myod.Developmental biology · 2011Article
- Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.Cell · 2010Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundMyoD is a transcription factor implicated in the regulation of adult muscle gene expression. Distinguishing the expression of MyoD in satellite myoblasts and muscle fibres has proved difficult in vivo leading to controversy over the significance of MyoD expression within adult innervated muscle fibres. Here we employ the MD6.0-lacZ transgenic mouse, in which the 6 kb proximal enhancer/promoter (DRR/PRR) of MyoD drives lacZ, to show that MyoD is present and transcriptionally active in many adult muscle fibres.
resultsIn culture, MD6.0-lacZ expresses in myotubes but not myogenic cells, unlike endogenous MyoD. Reporter expression in vivo is in muscle fibre nuclei and is reduced in MyoD null mice. The MD6.0-lacZ reporter is down-regulated both in adult muscle fibres by denervation or muscle disuse and in cultured myotubes by inhibition of activity. Activity induces and represses MyoD through the DRR and PRR, respectively. During the postnatal period, accumulation of beta-galactosidase correlates with maturation of innervation. Strikingly, endogenous MyoD expression is up-regulated in fibres by complete denervation, arguing for a separate activity-dependent suppression of MyoD requiring regulatory elements outside the DRR/PRR.
conclusionThe data show that MyoD regulation is more complex than previously supposed. Two factors, MyoD protein itself and fibre activity are required for essentially all expression of the 6 kb proximal enhancer/promoter (DRR/PRR) of MyoD in adult fibres. We propose that modulation of MyoD positive feedback by electrical activity determines the set point of MyoD expression in innervated fibres through the DRR/PRR element.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.