ReviewThe American journal on addictions
Neurobiological processes in adolescent addictive disorders.
Review in The American journal on addictions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial.BMC psychiatry · 2026Trial
- Ultra-processed food addiction in a nationally representative sample of older adults in the USA.Addiction (Abingdon, England) · 2026Article
- Regulating addictive algorithms and designs: protecting older adults from digital exploitation beyond a youth-centric approach.Frontiers in psychology · 2025Article
- Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues.Scientific reports · 2024Article
- Association between vmPFC gray matter volume and smoking initiation in adolescents.Nature communications · 2023Article
- Longitudinal Analysis of Substance Use Disorder Symptom Severity at Age 18 Years and Substance Use Disorder in Adulthood.JAMA network open · 2022Article
- Article
- Managing Chronic Pain in Special Populations with Emphasis on Pediatric, Geriatric, and Drug Abuser Populations.The Medical clinics of North America · 2016Review
- Training in Substance-Related and Addictive Disorders, Part 1: Overview of Clinical Practice and General Recommendations.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2015Article
- The effect of the anabolic steroid, nandrolone, in conditioned place preference and D1 dopamine receptor expression in adolescent and adult mice.Behavioural processes · 2015Article
- Predicting Initiation of Smoking Cessation Treatment and Outcome Among Adolescents Using Stressful Life Events and Coping Style.Substance abuse · 2015Article
- Differences in regional cerebral blood flow response to a 5HT3 antagonist in early- and late-onset cocaine-dependent subjects.Addiction biology · 2014Article
- Translational neuroscience and potential contributions of functional magnetic resonance imaging (FMRI) to the prevention of substance misuse and antisocial behavior.Prevention science : the official journal of the Society for Prevention Research · 2013Article
- Caudolateral orbitofrontal regional cerebral blood flow is decreased in abstinent cocaine-addicted subjects in two separate cohorts.Addiction biology · 2012Article
- Substance abuse and suicide risk among adolescents.European archives of psychiatry and clinical neuroscience · 2012Review
- Delay discounting by adolescents experimenting with cigarette smoking.Addiction (Abingdon, England) · 2012Article
- Co-occurring risk behaviors among White, Black, and Hispanic US high school adolescents with suicide attempts requiring medical attention, 1999-2007: implications for future prevention initiatives.Social psychiatry and psychiatric epidemiology · 2012Article
- Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents.Psychopharmacology · 2012Article
- Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders.Journal of clinical and experimental neuropsychology · 2012Article
- Verbal learning and memory in adolescent cannabis users, alcohol users and non-users.Psychopharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The purpose of this review is to summarize the neurobiological factors involved in the etiology of adolescent addiction and present evidence implicating various mechanisms in its development. Adolescents are at heightened risk for experimentation with substances, and early experimentation is associated with higher rates of SUD in adulthood. Both normative (e.g., immature frontal-limbic connections, immature frontal lobe development) and non-normative (e.g., lowered serotonergic function, abnormal hypothalamic-pituitary-adrenal axis function) neurobiological developmental factors can predispose adolescents to a heightened risk for SUD. In addition, a normative imbalance in the adolescent neurobiological motivational system may be caused by the relative underdevelopment of suppressive mechanisms when compared to stimulatory systems. These neurobiological liabilities may correspond to neurobehavioral impairments in decision-making, affiliation with deviant peers and externalizing behavior; these and other cognitive and behavioral traits converge with neurobiological factors to increase SUD risk. The progression to SUD acts as an amplifying feedback loop, where the development of SUD results in reciprocal impairments in neurobehavioral and neurobiological processes. A clearer understanding of adolescent neurobiology is a necessary step in the development of prevention and treatment interventions for adolescent SUD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.