ArticleJournal of bioenergetics and biomembranes2008
Homocysteine is a potent modulator of plasma membrane electron transport systems.
Article in Journal of bioenergetics and biomembranes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Homocysteine pre-treatment increases redox capacity in both endothelial and tumor cells.Redox report : communications in free radical research · 2017Article
- Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- Evidence for functional interaction of plasma membrane electron transport, voltage-dependent anion channel and volume-regulated anion channel in frog aorta.Journal of biosciences · 2010Article
- Circadian blood pressure variability in type 1 diabetes subjects and their nondiabetic siblings - influence of erythrocyte electron transfer.Cardiovascular diabetology · 2010Article
- Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Two types of seizures in homocysteine thiolactone-treated adult rats, behavioral and electroencephalographic study.Cellular and molecular neurobiology · 2009Article
- Ox-PAPC activation of PMET system increases expression of heme oxygenase-1 in human aortic endothelial cell.Journal of lipid research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The deregulation of homocysteine metabolism leads to hyperhomocysteinemia, a condition described as an independent cardiovascular disease risk factor. Ubiquitous plasma membrane redox systems can play a dual pro-oxidant and anti-oxidant role in defense. In this study, we test the hypothesis that homocysteine, as a redox active compound, could modulate the endothelial plasma membrane redox system. We show that homocysteine behaves as a very potent stimulator of this activity. Furthermore, we show that this inducing effect is also produced on tumor cells and that it can be observed at both the activity and protein levels. On the other hand, homocysteine treatment decreases the activity of the specific ectocellular tumor NADH oxidase. Taken together, these results underscore a potential antitumoral action of homocysteine.
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