ArticleMammalian genome : official journal of the International Mammalian Genome Society2008
Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals.Frontiers in neuroscience · 2021Review
- Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior.Neurochemistry international · 2019Review
- Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats.Psychopharmacology · 2016Article
- Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Advances in Medications and Tailoring Treatment for Alcohol Use Disorder.Alcohol research : current reviews · 2015Review
- Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.Alcoholism, clinical and experimental research · 2014Article
- Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons.Alcoholism, clinical and experimental research · 2014Article
- Mesolimbic transcriptional response to hedonic substitution of voluntary exercise and voluntary ethanol consumption.Behavioural brain research · 2014Article
- Expression, covariation, and genetic regulation of miRNA Biogenesis genes in brain supports their role in addiction, psychiatric disorders, and disease.Frontiers in genetics · 2013Article
- Increased consumption of ethanol and sugar water in mice lacking the dopamine D2 long receptor.Alcohol (Fayetteville, N.Y.) · 2011Article
- Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.Alcoholism, clinical and experimental research · 2011Article
- Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking rats.Alcohol (Fayetteville, N.Y.) · 2010Article
- Event-related oscillations as risk markers in genetic mouse models of high alcohol preference.Neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The high alcohol-preferring (HAP) and low alcohol-preferring (LAP) mice were selectively bred for differences in alcohol preference and consumption. Recently, a large-effect QTL was identified on chromosome 9. The peak for this QTL is near the Drd2 (dopamine receptor 2) locus. The present study examined Drd2 mRNA expression differences between the HAP1 and LAP1 mice in brain regions important in the dopaminergic-reward pathway, including the nucleus accumbens, hippocampus, amygdala, and septum. Results show that alcohol-naïve HAP1 mice exhibited lower levels of Drd2 mRNA expression in the nucleus accumbens and the hippocampus compared to LAP1 mice. No differences were found in the amygdala or septum. To determine if a sequence difference might underlie the expression difference, the Drd2 cDNA was sequenced in each line and one single nucleotide polymorphism (SNP) was identified in the 3' UTR. Both HAP and LAP 3' UTR were cloned in the luc-pGL3-promoter-luc vector. The polymorphism in the Drd2 3' UTR was assessed to determine its functional significance in modulating expression. In vitro expression analysis using neuroblastoma SK-N-SH cells resulted in a significant decrease in expression of the HAP 3' UTR luc construct compared with the LAP 3' UTR construct. This decreased expression is consistent with lower levels of Drd2 expression in the nucleus accumbens and the hippocampus as evidenced by qRT-PCR. These results suggest that the SNP may play a role in the differential expression of Drd2 between the HAP and LAP mice and that the polymorphism in Drd2 may contribute to alcohol preference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.