ArticleDocumenta ophthalmologica. Advances in ophthalmology2008
The photopic negative response of flash ERG in nonproliferative diabetic retinopathy.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 49 citations in OpenAlex.
- Association and Multimodal Model of Retinal Mid-Peripheral Capillary Free Zones with Structural and Functional Parameters in Diabetic Patients Without Clinical Retinopathy.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Effects of Selected Antioxidants on Electroretinography in Rodent Diabetic Retinopathy.Antioxidants (Basel, Switzerland) · 2024Review
- Early Alterations in Inner-Retina Neural and Glial Saturated Responses in Lens-Induced Myopia.Translational vision science & technology · 2024Article
- Electrophysiological findings in long-term type 1 diabetes patients without diabetic retinopathy using different ERG recording systems.Scientific reports · 2024Article
- Retinal Functional Impairment in Diabetic Retinopathy.Biomedicines · 2023Article
- Pre-stimulus bioelectrical activity in light-adapted ERG under blue versus white background.Visual neuroscience · 2023Article
- Visual Evoked Potentials for the Detection of Diabetic Retinal Neuropathy.International journal of molecular sciences · 2023Review
- Intravitreal Fluocinolone Acetonide for Diabetic Macular Edema: Long-Term Effect and Structure/Function Correlation.Diagnostics (Basel, Switzerland) · 2022Article
- Structural and functional changes among diabetics with no diabetic retinopathy and mild non-proliferative diabetic retinopathy using swept-source optical coherence tomography angiography and photopic negative response.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy.Nutrients · 2022Review
- Comparison of broadband and monochromatic photopic negative response in eyes of patients with diabetes with no diabetic retinopathy and different stages of diabetic retinopathy.Indian journal of ophthalmology · 2021Article
- Clinical electrophysiology of the optic nerve and retinal ganglion cells.Eye (London, England) · 2021Review
- Article
- Combined Intravitreal Dexamethasone Implant and Cataract Surgery in Patients with Diabetic Retinopathy: Effect on Retinal Morphology and Function.Advances in therapy · 2020Observational
- The photopic negative response of the Light-adapted 3.0 ERG in clinical settings.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Electrophysiological measures of dysfunction in early-stage diabetic retinopathy: No correlation between cone phototransduction and oscillatory potential abnormalities.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2019Article
- Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram.Investigative ophthalmology & visual science · 2019Article
- Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response.Translational vision science & technology · 2018Article
- Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography.Investigative ophthalmology & visual science · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo test how the PhNR of the flash ERG is affected in human nonproliferative diabetic retinopathy (NPDR).
methodsThe PhNR was elicited with red stimuli (5 cd s/m(2) with 4-min duration) and blue background (10 cd/m(2)). Standard Ganzfeld flash ERGs were recorded according to the ISCEV standard for the clinical electroretinogram (2004). A total of 81 diabetic patients with different severity levels of NPDR were examined. Forty-three age-matched normal controls were also studied.
resultsThe amplitude of PhNR decreased significantly as DR progressed, while the implicit time was prolonged. Amplitudes of the PhNR in the control group, no DR, mild NPDR, moderate NPDR, and severe NPDR were 78.1 +/- 15.1 microV, 69.0 +/- 17.8 microV, 64.5 +/- 13.2 microV, 45.9 +/- 9.0 microV, and 33.7 +/- 10.8 muV respectively, and the implicit times of PhNR were 71.5 +/- 5.0, 72.0 +/- 6.2, 73.6 +/- 5.0, 75.7 +/- 6.1, and 82.9 +/- 7.8 min respectively. Compared to the control group, the reduction of PhNR amplitude in all diabetic groups was statistically significant. However, except for the OPs, the percent reduction of the amplitude of standard ERG waves was far less than that of the PhNR. The percent decrease in amplitude of the PhNR and summation OPs was not significantly different in any diabetic group. However, the reduction of the amplitude of summation OPs (and other standard ERG waves) was statistically significant only in moderate and severe NPDR groups.
conclusionsPhNR is a sensitive indicator of the function of inner retina in diabetic patients. There is a potential role for the PhNR in assessing inner retinal damage and evaluating the effect of treatment in NPDR.
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