ArticleEmerging infectious diseases2007
Ongoing genome reduction in Mycobacterium ulcerans.
Article in Emerging infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The mycobacterial selenocysteine machinery: presence and expression.RNA biology · 2026Article
- ProfilingFuture science OA · 2023Review
- Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin.Emerging infectious diseases · 2020Article
- Genome Reduction for Niche Association inFrontiers in cellular and infection microbiology · 2017Article
- Article
- Methodological and Clinical Aspects of the Molecular Epidemiology of Mycobacterium tuberculosis and Other Mycobacteria.Clinical microbiology reviews · 2016Review
- Genotyping Tools forMycobacterial diseases : tuberculosis & leprosy · 2014Article
- Insertion sequence element single nucleotide polymorphism typing provides insights into the population structure and evolution of Mycobacterium ulcerans across Africa.Applied and environmental microbiology · 2014Article
- Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mapé Basin of Cameroon.PLoS neglected tropical diseases · 2013Article
- Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of genotypes A1 and E (WB and Pig).Genome biology and evolution · 2013Article
- Development of a temperature-switch PCR-based SNP typing method for Mycobacterium ulcerans.PLoS neglected tropical diseases · 2012Article
- Sero-epidemiology as a tool to screen populations for exposure to Mycobacterium ulcerans.PLoS neglected tropical diseases · 2012Article
- Horizontal gene transfers with or without cell fusions in all categories of the living matter.Advances in experimental medicine and biology · 2011Review
- Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.PLoS neglected tropical diseases · 2010Article
- Lack of insertional-deletional polymorphism in a collection of Mycobacterium ulcerans isolates from Ghanaian Buruli ulcer patients.Journal of clinical microbiology · 2009Article
- Single nucleotide polymorphisms on the road to strain differentiation in Mycobacterium ulcerans.Journal of clinical microbiology · 2009Article
- Computational resources in infectious disease: limitations and challenges.PLoS computational biology · 2009Review
- Genomic diversity and evolution of Mycobacterium ulcerans revealed by next-generation sequencing.PLoS pathogens · 2009Article
- Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to Mycobacterium ulcerans.Applied and environmental microbiology · 2009Article
- Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans.Nature reviews. Microbiology · 2009Review
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Elucidation of the transmission, epidemiology, and evolution of Mycobacterium ulcerans, the causative agent of Buruli ulcer, is hampered by the striking lack of genetic diversity of this emerging pathogen. However, by using a prototype plasmid-based microarray that covered 10% of the genome, we found multiple genomic DNA deletions among 30 M. ulcerans clinical isolates of diverse geographic origins. Many of the changes appear to have been mediated by insertion sequence (IS) elements IS2404 and IS2606, which have high copy numbers. Classification of the deleted genes according to their biological functions supports the hypothesis that M. ulcerans has recently evolved from the generalist environmental M. marinum to become a niche-adapted specialist. The substantial genomic diversity, along with a prototype microarray that covered a small portion of the genome, suggests that a genome-wide microarray will make available a genetic fingerprinting method with the high resolution required for microepidemiologic studies.
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