ReviewImmunologic research2008
The effector to memory transition of CD4 T cells.
Review in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- B- and T-cell memory elicited by a seasonal live attenuated reassortant influenza vaccine: assessment of local antibody avidity and virus-specific memory T-cells using trogocytosis-based method.Influenza and other respiratory viruses · 2012Trial
- Article
- Signatures and Prognostic Values of N6-methyladenosine (m6A) - related Immune Genes in Bladder Cancer.Bioengineered · 2021Article
- In Vitro Models for Studying Respiratory Host-Pathogen Interactions.Advanced biology · 2021Review
- A multiple T cell epitope comprising DNA vaccine boosts the protective efficacy of Bacillus Calmette-Guérin (BCG) against Mycobacterium tuberculosis.BMC infectious diseases · 2020Article
- Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.PLoS pathogens · 2019Article
- Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4Frontiers in immunology · 2019Review
- Cigarette smoke extract acts directly on CD4 T cells to enhance Th1 polarization and reduce memory potential.Cellular immunology · 2018Article
- Early programming and late-acting checkpoints governing the development of CD4 T-cell memory.Immunology · 2018Review
- Disabling of lymphocyte immune response by Ebola virus.PLoS pathogens · 2018Article
- Trying to See the Forest through the Trees: Deciphering the Nature of Memory Immunity toFrontiers in immunology · 2018Review
- Article
- Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells.Cancer research · 2012Article
- Expanding roles for CD4⁺ T cells in immunity to viruses.Nature reviews. Immunology · 2012Review
- Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells.Current opinion in HIV and AIDS · 2012Review
- Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.Immunity · 2011Article
- Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations.The Journal of experimental medicine · 2011Article
- Control of innate immunity by memory CD4 T cells.Advances in experimental medicine and biology · 2011Review
- Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells.International immunology · 2010Review
- Regulation of CD4+ T-cell contraction during pathogen challenge.Immunological reviews · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The small number of antigen-specific memory CD4 T cells surviving long-term after antigen or pathogen challenge are often characterized by a surprising degree of phenotypic and functional heterogeneity. We here propose that the immune system has evolved to express this diversity in memory T-cell populations, in order to provide flexibility in recall responses, via a rapid transition from heterogeneous effector cells into correspondingly heterogeneous memory cells. Little attention has been paid to another important transition-from resting memory cell to re-activated effector. We would suggest that superior functional attributes of secondary effectors arising from memory CD4 T cells, as compared to primary effectors arising from naïve precursors, play an important and underappreciated role in protective secondary immune responses.
Indexed as
Identifiers
18213525What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.