ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2008
Video-rate two-photon imaging of mouse footpad - a promising model for studying leukocyte recruitment dynamics during inflammation.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Label-free multiphoton microscopy of human skin: longitudinal studies capturing cell dynamics.Biomedical optics express · 2025Article
- Monitoring Circulating Myeloid Cells in Peritonitis with an In Vivo Imaging Flow Cytometer.Biomolecules · 2024Article
- Intravital imaging to study cancer progression and metastasis.Nature reviews. Cancer · 2023Review
- Listeria motility increases the efficiency of epithelial invasion during intestinal infection.PLoS pathogens · 2022Article
- Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis.Frontiers in immunology · 2022Article
- Guideline for in vivo assessment of adherent and rolling leukocytes in human skin microvasculature via reflectance confocal videomicroscopy.Microcirculation (New York, N.Y. : 1994) · 2021Article
- Review
- Development of an intravital imaging system for the synovial tissue reveals the dynamics of CTLA-4 Ig in vivo.Scientific reports · 2020Article
- Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.Particle and fibre toxicology · 2020Article
- The Secretive Life of Neutrophils Revealed by Intravital Microscopy.Frontiers in cell and developmental biology · 2020Review
- Review
- Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics.Methods (San Diego, Calif.) · 2017Article
- Two-photon microscopy for intracutaneous imaging of stem cell activity in mice.Experimental dermatology · 2017Review
- Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis.The Journal of experimental medicine · 2016Review
- Video-rate in vivo fluorescence imaging with a line-scanned dual-axis confocal microscope.Journal of biomedical optics · 2015Article
- In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy.Biomedical optics express · 2015Article
- Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.Nature medicine · 2014Article
- A method for noninvasive longitudinal measurements of [Ca2+] in arterioles of hypertensive optical biosensor mice.American journal of physiology. Heart and circulatory physiology · 2014Article
- Multi-scale optical imaging of the delayed type hypersensitivity reaction attenuated by rapamycin.Theranostics · 2014Article
- Stereotaxic device for optical imaging of mice hind feet.Journal of biomolecular techniques : JBT · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Leukocyte recruitment is a key host defense mechanism to infection and a salient feature of autoimmune diseases such as arthritis. The cell dynamics of these processes are difficult to study due to the challenge of tracking cells flowing in the circulation and migrating through light scattering tissues. Here, we describe a noninvasive two-photon (2P) microscopy approach to study leukocyte homing in the mouse footpad. In the absence of inflammation, cells moved > several hundred microm/s in vessels and only rarely adhered to endothelium or entered the tissue parenchyma. In response to bacterial infection, neutrophils moved in small capillaries at reduced speeds of (14-45 microm/min) and rolled in larger vessels at 5-60 microm/min. Within minutes of adoptive transfer, neutrophils entered the connective tissue and crawled with a median velocity of 7.3 microm/min. 2P imaging has excellent spatiotemporal resolution and is a promising in vivo approach to study the cellular basis of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.