ArticlePloS one2008
Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Developmental perfluorooctanesulfonic acid exposure impairs exocrine pancreas function in zebrafish (Danio rerio).Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Hydrogen Peroxide and Redox Regulation of Developments.Antioxidants (Basel, Switzerland) · 2018Review
- Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos.Molecules and cells · 2017Article
- Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing.BMC genomics · 2013Article
- Article
- The Notch signalling system: recent insights into the complexity of a conserved pathway.Nature reviews. Genetics · 2012Review
- Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation.PloS one · 2010Article
- Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- On the diabetic menu: zebrafish as a model for pancreas development and function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Review
- Transcriptome analysis of the zebrafish mind bomb mutant.Molecular genetics and genomics : MGG · 2009Article
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNotch signaling is an evolutionarily conserved developmental pathway. Zebrafish mind bomb (mib) mutants carry mutations on mib gene, which encodes a RING E3 ligase required for Notch activation via Delta/Jagged ubiquitylation and internalization. METHODOLOGY/PRINCIPAL
findingsWe examined the mib mutants for defects in pancreas development using in situ hybridization and GFP expression analysis of pancreas-specific GFP lines, carried out the global gene expression profile analysis of three different mib mutant alleles and validated the microarray data using real-time PCR and fluorescent double in situ hybridization. Our study showed that the mib mutants have diminished exocrine pancreas and this defect was most severe in mib(ta52b) followed by mib(m132) and then mib(tfi91), which is consistent with the compromised Notch activity found in corresponding mib mutant alleles. Global expression profile analysis of mib mutants showed that there is a significant difference in gene expression profile of wt and three mib mutant alleles. There are 91 differentially expressed genes that are common to all three mib alleles. Through detailed analysis of microarray data, we have identified several previously characterized genes and some putative Notch-responsive genes involved in pancreas development. Moreover, results from real-time PCR and fluorescent double in situ hybridization were largely consistent with microarray data. CONCLUSIONS/SIGNIFICANCE: This study provides, for the first time, a global gene expression profile in mib mutants generating useful genomic resources and providing an opportunity to identify the function of novel genes involved in Notch signaling and Notch-regulated developmental processes.
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