ArticleBritish journal of cancer2008
Utility of malignancy markers in fine-needle aspiration cytology of thyroid nodules: comparison of Hector Battifora mesothelial antigen-1, thyroid peroxidase and dipeptidyl aminopeptidase IV.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Systematic Review and Meta-Analysis to Identify the Immunocytochemical Markers Effective in Delineating Benign from Malignant Thyroid Lesions in FNAC Samples.Endocrine pathology · 2022Pooled it
- Expression of CK-19, galectin-3 and HBME-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis.Diagnostic pathology · 2012Pooled it
- TPO as an indicator of lymph node metastasis and recurrence in papillary thyroid carcinoma.Scientific reports · 2023Article
- Integrative Analysis of Potential Biomarkers Involved in the Progression of Papillary Thyroid Cancer.Applied biochemistry and biotechnology · 2023Article
- Hyalinizing trabecular tumor of the thyroid gland.Turkish journal of surgery · 2018Article
- Combination of galectin-3, CK19 and HBME-1 immunostaining improves the diagnosis of thyroid cancer.Oncology letters · 2017Article
- Altered peptidase activities in thyroid neoplasia and hyperplasia.Disease markers · 2013Article
- Three-gene molecular diagnostic model for thyroid cancer.Thyroid : official journal of the American Thyroid Association · 2012Article
- Validity of multiplex biomarker model of 6 genes for the differential diagnosis of thyroid nodules.Thyroid research · 2011Article
- Diagnostic utility of immunohistochemical panel in various thyroid pathologies.Langenbeck's archives of surgery · 2010Article
- Thyroid fine needle aspiration biopsies in children: study of cytological-histological correlation and immunostaining with thyroid peroxidase monoclonal antibodies.International journal of pediatric endocrinology · 2010Article
- On the origin of serum CD26 and its altered concentration in cancer patients.Cancer immunology, immunotherapy : CII · 2009Review
- Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns.Journal of proteome research · 2009Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to compare the diagnostic interest of Hector Battifora mesothelial antigen-1 (HBME-1), thyroid peroxidase (TPO), and dipeptidyl aminopeptidase IV (DPP4) in thyroid fine-needle aspirates obtained from 200 resected thyroid lesions (55 colloid nodules, 54 follicular adenomas, 59 papillary cancers, and 32 follicular carcinomas). Hector Battifora mesothelial antigen-1 or TPO expression (% positive cells) and DPP4 staining score (12-point scale) were evaluated. Receiver operating characteristic (ROC) curves were plotted and optimal cutoff values for diagnosing malignancy were determined. The TPO ROC curve was consistently higher than the HBME-1 ROC curve. The TPO curve was also higher than the DPP4 curve with regard to sensitivity, but dipped below the DPP4 curve with regard to specificity. Using a cutoff value of <80% positive cells for TPO, >10% positive cells for HBME-1, and staining score > or =1 for DPP4, sensitivity to specificity ratios were 98-83% for TPO, 90-60% for HBME-1, and 88-80% for DPP4. Two particularly interesting findings of this study were the low negative likelihood ratio of TPO (0.02) allowing highly reliable exclusion of malignancy and the 100% specificity of DPP4 staining scores=12. Due to poor performance on follicular lesions, HBME-1 showed no advantage over TPO or DPP4.
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