ArticleBritish journal of cancer2008
Detection of human parvovirus B19 in papillary thyroid carcinoma.
Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- Investigating the Relationship Human Parvovirus B19 Infection in Benign and Malignant Salivary Gland Tumors.Journal of dentistry (Shiraz, Iran) · 2026Article
- Human parvovirus B19 infection in malignant and benign tissue specimens of different head and neck anatomical subsites.Infectious agents and cancer · 2023Article
- Detection of Human Boca Virus in Gastric Adenocarcinoma.Middle East journal of digestive diseases · 2023Article
- Medical Applications of Molecular Biotechnologies in the Context of Hashimoto's Thyroiditis.Diagnostics (Basel, Switzerland) · 2023Review
- Viruses and Endocrine Diseases.Microorganisms · 2023Review
- Investigation of Parvovirus B19, Cytomegalovirus, Herpes Simplex Virus Types 1 and 2, Human Papillomavirus Types 16 and 18 in Papillary Thyroid Carcinoma.Iranian journal of pathology · 2023Article
- Effects of solid organ transplantation on the risk of developing thyroid cancer: a systematic review and meta-analysis.Gland surgery · 2022Article
- The Pathogenic Aspects of Human Parvovirus B19 NS1 Protein in Chronic and Inflammatory Diseases.Interdisciplinary perspectives on infectious diseases · 2022Article
- Parvovirus B19 Infection Is Associated with Autoimmune Thyroid Disease in Adults.International journal of endocrinology and metabolism · 2021Article
- Detection of Human Papillomavirus in Papillary Thyroid Carcinoma and its Association with Tumor Staging and Pathologic Features.Iranian journal of medical sciences · 2021Article
- Presence of B19V in Patients with Thyroid Gland Disorders.Medicina (Kaunas, Lithuania) · 2019Article
- Association of the Human Bocavirus With Tonsil Squamous Cell Carcinomas.Frontiers in microbiology · 2018Article
- Recent Advances in Replication and Infection of Human Parvovirus B19.Frontiers in cellular and infection microbiology · 2018Review
- Environmental Issues in Thyroid Diseases.Frontiers in endocrinology · 2017Review
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- The role of human parvovirus B19 and hepatitis C virus in the development of thyroid disorders.Reviews in endocrine & metabolic disorders · 2016Review
- Lung Infection by Human Bocavirus Induces the Release of Profibrotic Mediator Cytokines In Vivo and In Vitro.PloS one · 2016Article
- Article
- Hepatic inflammation resulting from localized, subcutaneous expression of Parvovirus VP1u capsid protein: Importance and implication.Virulence · 2016Article
- Parvovirus b19 persistence in abnormal thyroid tissue of a mature cystic ovarian teratoma: a case report.Endocrine pathology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate whether parvovirus B19, a common human pathogen, was also involved in papillary thyroid carcinoma (PTC), 112 paraffin-embedded thyroid specimens of benign nodules, papillary, medullary and follicular carcinomas, and normal controls were examined for B19 DNA and capsid protein by nested PCR, in situ hybridisation (ISH) and immunohistochemistry (IHC). The expression of the nuclear factor-kappaB (NF-kappaB) was investigated by IHC. The results showed B19 DNA commonly exists in human thyroid tissues; however, there were significant differences between PTC group and normal controls, and between PTC and nonneoplastic adjacent tissues (P<0.001). The presence of viral DNA in PTC neoplastic epithelium was confirmed by laser-capture microdissection and sequencing of nested PCR products. B19 capsid protein in PTC group was significantly higher than that of all the control groups and nonneoplastic adjacent tissues (P<or=0.001). Compared with control groups, the activation of NF-kappaB in PTC group was significantly increased (P<or=0.02), except for medullary carcinomas, and the activation of NF-kappaB was correlated with the viral protein presence (P=0.002). Moreover, NF-kappaB was colocalised with B19 DNA in the neoplastic epithelium of PTC by double staining of IHC and ISH. These results indicate for the first time a possible role of B19 in pathogenesis of PTC.
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