ArticleAntimicrobial agents and chemotherapy2008
Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- CRISPR-Cas systems in combating antimicrobial resistance: which system to choose? A systematic review.World journal of microbiology & biotechnology · 2025Pooled it
- Whole-genome sequencing ofMicrobiology spectrum · 2026Article
- Subinhibitory Concentrations of Rifampicin Synergize with Linezolid to Delay Resistance Evolution in Clinical Methicillin-Resistant Staphylococcus Aureus.Microorganisms · 2026Article
- Prevalence and antimicrobial susceptibility ofOne health (Amsterdam, Netherlands) · 2026Article
- Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus.Genome biology · 2026Article
- The first genomic characterization of a stable, hemin-dependent small colony variant strain ofFrontiers in microbiology · 2023Article
- Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung.Infection and immunity · 2022Article
- Characterization of SCCAntimicrobial agents and chemotherapy · 2022Article
- How to survive pig farming: Mechanism of SCCFrontiers in microbiology · 2022Article
- Characterizing a Novel Staphylococcal Cassette ChromosomeAntimicrobial agents and chemotherapy · 2021Article
- Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations.PLoS pathogens · 2021Article
- Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin SusceptiblePathogens (Basel, Switzerland) · 2020Article
- Methicillin-ResistantFrontiers in microbiology · 2019Article
- Microbiological and genotypic factors affecting mortality in methicillin-resistant Staphylococcus aureus bacteremia.The Korean journal of internal medicine · 2019Article
- Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediateInfection and drug resistance · 2018Article
- Next-Generation Sequence Analysis Reveals Transfer of Methicillin Resistance to a Methicillin-Susceptible Staphylococcus aureus Strain That Subsequently Caused a Methicillin-Resistant Staphylococcus aureus Outbreak: a Descriptive Study.Journal of clinical microbiology · 2017Article
- Tandem Amplification of the Staphylococcal Cassette ChromosomeAntimicrobial agents and chemotherapy · 2017Article
- Influence of ISAntimicrobial agents and chemotherapy · 2017Article
- A potential role of transposon IS431 in the loss of mecA gene.Scientific reports · 2017Article
- Daptomycin Resistance in Clinical MRSA Strains Is Associated with a High Biological Fitness Cost.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Treatment of infections caused by Staphylococcus aureus is often confounded by the bacterium's ability to develop resistance to chemotherapeutic agents. Methicillin-resistant S. aureus (MRSA) arises through the acquisition of staphylococcal chromosomal cassette mec (SCCmec), a genomic island containing the methicillin resistance determinant, mecA. In contrast, resistance to vancomycin can result from exposure to the drug, a mechanism that is not dependent upon a gene acquisition event. Here we describe three MRSA strains that became resistant to vancomycin during passage in the presence of increasing concentrations of the drug. In each case two derivative strains were isolated, one that had lost mecA and one that retained mecA during passage. Strain 5836VR lost mecA by the site-specific chromosomal excision of SCCmec, while the other two strains (strains 3130VR and VP32) deleted portions of their SCCmec elements in a manner that appeared to involve IS431. Conversion to vancomycin resistance caused a decrease in the growth rate that was partially compensated for by the deletion of mecA. In mixed-culture competition experiments, vancomycin-resistant strains that lacked mecA readily outcompeted their mecA-containing counterparts, suggesting that the loss of mecA during conversion to vancomycin resistance was advantageous to the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.