ArticleBiophysical journal2008
Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films. I. Micro- and nanostructures of functional pulmonary surfactant films and the effect of SP-A.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Surface Symphony: Orchestrating DPPC/DOPC Monolayer Behavior.Microscopy research and technique · 2026Article
- The pristine unused pulmonary surfactant isolated from human amniotic fluid forms highly condensed interfacial films.Physiological reports · 2025Article
- The biophysical function of pulmonary surfactant.Biophysical journal · 2024Review
- Phase transitions of the pulmonary surfactant film at the perfluorocarbon-water interface.Biophysical journal · 2023Article
- A Deeper Insight into the Interfacial Behavior and Structural Properties of Mixed DPPC/POPC Monolayers: Implications for Respiratory Health.Membranes · 2022Article
- Nanoscale Chemical Imaging of Supported Lipid Monolayers using Tip-Enhanced Raman Spectroscopy.Angewandte Chemie (International ed. in English) · 2021Article
- Atomic Force Microscopy Imaging of Adsorbed Pulmonary Surfactant Films.Biophysical journal · 2020Article
- Graphene-based sensing of oxygen transport through pulmonary membranes.Nature communications · 2020Article
- Adsorption of Phospholipids at the Air-Water Surface.Biophysical journal · 2019Article
- Electronic cigarette vapor alters the lateral structure but not tensiometric properties of calf lung surfactant.Respiratory research · 2017Article
- Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia.Antimicrobial agents and chemotherapy · 2015Article
- The mechanism of collapse of heterogeneous lipid monolayers.Biophysical journal · 2014Article
- A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant.Biochimica et biophysica acta · 2012Article
- Biophysical interaction between corticosteroids and natural surfactant preparation: implications for pulmonary drug delivery using surfactant a a carrier.Soft matter · 2012Article
- Adverse biophysical effects of hydroxyapatite nanoparticles on natural pulmonary surfactant.ACS nano · 2011Article
- On the low surface tension of lung surfactant.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Comparative study of clinical pulmonary surfactants using atomic force microscopy.Biochimica et biophysica acta · 2011Article
- Lung surfactant protein SP-B promotes formation of bilayer reservoirs from monolayer and lipid transfer between the interface and subphase.Biophysical journal · 2011Article
- Reversible formation of nanodomains in monolayers of DPPC studied by kinetic modeling.Biophysical journal · 2009Article
- Perturbation of DPPC/POPG bilayers by the N-terminal helix of lung surfactant protein SP-B: a (2)H NMR study.European biophysics journal : EBJ · 2009Article
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7 authors.
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Abstract
Monolayers of a functional pulmonary surfactant (PS) can reach very low surface tensions well below their equilibrium value. The mechanism by which PS monolayers reach such low surface tensions and maintain film stability remains unknown. As shown previously by fluorescence microscopy, phospholipid phase transition and separation seem to be important for the normal biophysical properties of PS. This work studied phospholipid phase transitions and separations in monolayers of bovine lipid extract surfactant using atomic force microscopy. Atomic force microscopy showed phospholipid phase separation on film compression and a monolayer-to-multilayer transition at surface pressure 40-50 mN/m. The tilted-condensed phase consisted of domains not only on the micrometer scale, as detected previously by fluorescence microscopy, but also on the nanometer scale, which is below the resolution limits of conventional optical methods. The nanodomains were embedded uniformly within the liquid-expanded phase. On compression, the microdomains broke up into nanodomains, thereby appearing to contribute to tilted-condensed and liquid-expanded phase remixing. Addition of surfactant protein A altered primarily the nanodomains and promoted the formation of multilayers. We conclude that the nanodomains play a predominant role in affecting the biophysical properties of PS monolayers and the monolayer-to-multilayer transition.
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