ArticleGenome biology2008
Towards defining the nuclear proteome.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Nipple aspirate fluid-A liquid biopsy for diagnosing breast health.Proteomics. Clinical applications · 2017Trial
- Macrophages transfer functional proteins to their surface during live-cell uptake.Nature chemical biology · 2026Article
- Privileged proteins with a second residence: dual targeting and conditional re-routing of mitochondrial proteins.The FEBS journal · 2024Review
- Article
- Analysis of insect nuclear small heat shock proteins and interacting proteins.Cell stress & chaperones · 2021Article
- Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.Proteomics · 2018Article
- Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.Cell metabolism · 2017Article
- Tomato nuclear proteome reveals the involvement of specific E2 ubiquitin-conjugating enzymes in fruit ripening.Genome biology · 2014Article
- DLocalMotif: a discriminative approach for discovering local motifs in protein sequences.Bioinformatics (Oxford, England) · 2013Article
- Article
- NSort/DB: an intranuclear compartment protein database.Genomics, proteomics & bioinformatics · 2012Article
- Sorting the nuclear proteome.Bioinformatics (Oxford, England) · 2011Article
- A probabilistic model of nuclear import of proteins.Bioinformatics (Oxford, England) · 2011Article
- The proteins of intra-nuclear bodies: a data-driven analysis of sequence, interaction and expression.BMC systems biology · 2010Article
- Development of a high-throughput method for the systematic identification of human proteins nuclear translocation potential.BMC cell biology · 2009Article
- Statistical and visual differentiation of subcellular imaging.BMC bioinformatics · 2009Article
- Protein-protein interaction as a predictor of subcellular location.BMC systems biology · 2009Article
- Identification and correction of abnormal, incomplete and mispredicted proteins in public databases.BMC bioinformatics · 2008Article
- Mapping of protein- and chromatin-interactions at the nuclear lamina.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nucleus is a complex cellular organelle and accurately defining its protein content is essential before any systematic characterization can be considered.
resultsWe report direct evidence for 2,568 mammalian proteins within the nuclear proteome: the nuclear subcellular localization of 1,529 proteins based on a high-throughput subcellular localization protocol of full-length proteins and an additional 1,039 proteins for which clear experimental evidence is documented in published literature. This is direct evidence that the nuclear proteome consists of at least 14% of the entire proteome. This dataset was used to evaluate computational approaches designed to identify additional nuclear proteins.
conclusionThis represents direct experimental evidence that the nuclear proteome consists of at least 14% of the entire proteome. This high-quality nuclear proteome dataset was used to evaluate computational approaches designed to identify additional nuclear proteins. Based on this analysis, researchers can determine the stringency and types of lines of evidence they consider to infer the size and complement of the nuclear proteome.
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Registered trials
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