ArticleVirology journal2008
Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair.
Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair.International journal of molecular sciences · 2023Article
- Review
- An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?Journal of Alzheimer's disease : JAD · 2017Review
- Reconstructing the temporal progression of HIV-1 immune response pathways.Bioinformatics (Oxford, England) · 2016Article
- Activation of the DNA Damage Response by RNA Viruses.Biomolecules · 2016Review
- Article
- Rapid evolution of BRCA1 and BRCA2 in humans and other primates.BMC evolutionary biology · 2014Article
- Cancer risk at low doses of ionizing radiation: artificial neural networks inference from atomic bomb survivors.Journal of radiation research · 2014Review
- DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition.Retrovirology · 2013Article
- Article
- Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 1.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- Up-regulation of HIV-1 transduction in nondividing cells by double-strand DNA break-inducing agents.Biotechnology letters · 2011Article
- Article
- Ancient and recent adaptive evolution of primate non-homologous end joining genes.PLoS genetics · 2010Article
- A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors.Virology journal · 2010Article
- A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4.Aging cell · 2010Article
- Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein.Human gene therapy · 2010Article
- DNA double strand break repair enzymes function at multiple steps in retroviral infection.Retrovirology · 2009Article
- Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR). We and others proposed that PIR hijacks the host cell double-strand DNA break (DSB) repair pathways. Nevertheless, the geometry of retroviral DNA integration differs considerably from that of DSB repair and so the precise role of host-cell mechanisms in PIR remains unclear. In the current study, we found that the Nijmegen breakage syndrome 1 protein (NBS1), an early sensor of DSBs, associates with HIV-1 DNA, recruits the ataxia telangiectasia-mutated (ATM) kinase, promotes stable retroviral transduction, mediates efficient integration of viral DNA and blocks integrase-dependent apoptosis that can arise from unrepaired viral-host DNA linkages. Moreover, we demonstrate that the ATM kinase, recruited by NBS1, is itself required for efficient retroviral transduction. Surprisingly, recruitment of the ATR kinase, which in the context of DSB requires both NBS1 and ATM, proceeds independently of these two proteins. A model is proposed emphasizing similarities and differences between PIR and DSB repair. Differences between the pathways may eventually allow strategies to block PIR while still allowing DSB repair.
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