ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2008
Field trial of a Pasteurella multocida extract vaccine in rabbits.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- In field evaluation of impact on clinical signs of an inactivated autogenous vaccine againstInternational journal of veterinary science and medicine · 2024Article
- Characterization of Pasteurella multocida isolated from dead rabbits with respiratory disease in Fujian, China.BMC veterinary research · 2019Article
- Alternative treatment of serious and mild Pasteurella multocida infection in New Zealand White rabbits.BMC veterinary research · 2014Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pasteurella multocida is a bacterial pathogen that can cause significant disease and subsequent effects on research activities involving rabbits. Although several vaccines have been tested under laboratory conditions, field trials of vaccines for the control of P. multocida in rabbits are few. We used a potassium thiocyanate extract (PTE) produced from P. multocida serotype D:3,12,15 to vaccinate Pasteurella-free rabbits at their introduction into a colony having endemic infection with P. multocida serotype A:3. Groups of 15 rabbits were vaccinated either SC or IN with 1.0 mg PTE once weekly for 3 wk. In addition a control group was sham-vaccinated IN with saline. After the last vaccine dose had been administered, rabbits were housed with the general colony of a facility with endemic pasteurellosis. Serum samples obtained before and 5 and 24 wk after the first dose of vaccine were evaluated by ELISA for anti-PTE IgG. Rabbits were euthanized if found in poor clinical condition, and all remaining rabbits were euthanized 24 wk after initial vaccination. Clinical disease typical of P. multocida infection was observed in 10 of 15 saline-vaccinated rabbits, 4 of 15 IN PTE-vaccinated rabbits, and 1 of 15 SC PTE-vaccinated rabbits. Bacterial culture of the nasopharynx at the time of necropsy was positive for P. multocida in 10 of 15 control rabbits, 5 of 15 IN PTE-vaccinated rabbits, and 1 of 15 SC PTE-vaccinated rabbits. Anti-PTE serum IgG activity had developed in both IN- and SC-vaccinated rabbits by 5 wk, with significantly lower activity by 24 wk after initial vaccination. IgG activity was significantly greater in rabbits vaccinated SC compared with controls or those vaccinated IN. In summary, PTE can be used to stimulate protective immunity to a heterologous strain of P. multocida, with stronger immunity generated by SC than IN vaccination.
Indexed as
Identifiers
18210993PMC2652619W2993933866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.