ArticleJournal of immunology (Baltimore, Md. : 1950)2008
In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.Cellular & molecular immunology · 2026Article
- The spread of interferon-γ in melanomas is highly spatially confined, driving nongenetic variability in tumor cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Long-distance modulation of bystander tumor cells by CD8Nature cancer · 2020Article
- KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects.Molecular immunology · 2019Article
- Characteristics and critical function of CD8+ T cells in the Toxoplasma-infected brain.Seminars in immunopathology · 2015Review
- Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis.Experimental cell research · 2015Article
- Kupfer-type immunological synapses in vivo: Raison D'être of SMAC.Immunology and cell biology · 2015Review
- Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.PloS one · 2014Article
- The great balancing act: regulation and fate of antiviral T-cell interactions.Immunological reviews · 2013Review
- Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation.Frontiers in cellular neuroscience · 2013Article
- Article
- Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas.Immunity · 2011Article
- The role of antigen presenting cells in multiple sclerosis.Biochimica et biophysica acta · 2011Review
- Article
- Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells.The American journal of pathology · 2010Article
- Trafficking of immune cells in the central nervous system.The Journal of clinical investigation · 2010Review
- Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Gene transfer into rat brain using adenoviral vectors.Current protocols in neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Kupfer-type immunological synapses are thought to mediate intercellular communication between antiviral T cells and virally infected target Ag-presenting brain cells in vivo during an antiviral brain immune response. This hypothesis predicts that formation of Kupfer-type immunological synapses is necessary for polarized distribution of effector molecules, and their directed secretion toward the target cells. However, no studies have been published testing the hypothesis that cytokines can only form polarized clusters at Kupfer-type immunological synapses. Here, we show that IFN-gamma and granzyme-B cluster in a polarized fashion at contacts between T cells and infected astrocytes in vivo. In some cases these clusters were found in Kupfer-type immunological synapses between T cells and infected astrocytes, but we also detected polarized IFN-gamma at synaptic immunological contacts which did not form Kupfer-type immunological synaptic junctions, i.e., in the absence of polarization of TCR or LFA-1. This indicates that TCR signaling, which leads to the production, polarization, and eventual directed secretion of effector molecules such as IFN-gamma, occurs following the formation of both Kupfer-type and non-Kupfer type immunological synaptic junctions between T cells and virally infected target astrocytes in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.