ArticleGenome biology2008
Gene expression variation in African and European populations of Drosophila melanogaster.
Article in Genome biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 104 citations in OpenAlex.
- Article
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- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila.PLoS genetics · 2024Article
- Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster.Genetics · 2023Article
- Ovarian transcriptional response to Wolbachia infection in D. melanogaster in the context of between-genotype variation in gene expression.G3 (Bethesda, Md.) · 2023Article
- Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster.BMC genomics · 2022Article
- Intraspecific Transcriptome Variation and Sex-Biased Expression in Anopheles arabiensis.Genome biology and evolution · 2021Article
- Identification of genes involved in inbreeding depression of reproduction in Langshan chickens.Animal bioscience · 2021Article
- Parallel gene expression evolution in natural and laboratory evolved populations.Molecular ecology · 2021Article
- Genotype by environment interaction for gene expression in Drosophila melanogaster.Nature communications · 2020Article
- Investigating population-scale allelic differential expression in wild populations ofEcology and evolution · 2020Article
- Transcriptome analysis ofEcology and evolution · 2020Article
- Additive and mostly adaptive plastic responses of gene expression to multiple stress in Tribolium castaneum.PLoS genetics · 2020Article
- Article
- Review
- Population Genetic and Functional Analysis of aGenes · 2019Article
- Genetic redundancy fuels polygenic adaptation in Drosophila.PLoS biology · 2019Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferences in levels of gene expression among individuals are an important source of phenotypic variation within populations. Recent microarray studies have revealed that expression variation is abundant in many species, including Drosophila melanogaster. However, previous expression surveys in this species generally focused on a small number of laboratory strains established from derived populations. Thus, these studies were not ideal for population genetic analyses.
resultsWe surveyed gene expression variation in adult males of 16 D. melanogaster strains from two natural populations, including an ancestral African population and a derived European population. Levels of expression polymorphism were nearly equal in the two populations, but a higher number of differences was detected when comparing strains between populations. Expression variation was greatest for genes associated with few molecular functions or biological processes, as well as those expressed predominantly in males. Our analysis also identified genes that differed in expression level between the European and African populations, which may be candidates for adaptive regulatory evolution. Genes involved in flight musculature and fatty acid metabolism were over-represented in the list of candidates.
conclusionOverall, stabilizing selection appears to be the major force governing gene expression variation within populations. However, positive selection may be responsible for much of the between-population expression divergence. The nature of the genes identified to differ in expression between populations may reveal which traits were important for local adaptation to the European and African environments.
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