ArticlePLoS genetics2008
Analysis and application of European genetic substructure using 300 K SNP information.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 3 of them syntheses that pooled it.
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Who cites it
169 citing papers in PubMed, 3 syntheses or guidelines pooled it, 252 citations in OpenAlex.
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- Scalable probabilistic PCA for large-scale genetic variation data.PLoS genetics · 2020Article
- Exploring Population Structure with Admixture Models and Principal Component Analysis.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Differential admixture in Latin American populations and its impact on the study of colorectal cancer.Genetics and molecular biology · 2020Article
- The Genetic Landscape of Dystrophin Mutations in Italy: A Nationwide Study.Frontiers in genetics · 2020Article
- Genetic history of the population of Crete.Annals of human genetics · 2019Article
- Distribution of local ancestry and evidence of adaptation in admixed populations.Scientific reports · 2019Article
109 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses (PCA) showed the largest division/principal component (PC) differentiated northern from southern European ancestry. A second PC further separated Italian, Spanish, and Greek individuals from those of Ashkenazi Jewish ancestry as well as distinguishing among northern European populations. In separate analyses of northern European participants other substructure relationships were discerned showing a west to east gradient. Application of this substructure information was critical in examining a real dataset in whole genome association (WGA) analyses for rheumatoid arthritis in European Americans to reduce false positive signals. In addition, two sets of European substructure ancestry informative markers (ESAIMs) were identified that provide substantial substructure information. The results provide further insight into European population genetic substructure and show that this information can be used for improving error rates in association testing of candidate genes and in replication studies of WGA scans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.