ArticlePLoS genetics2008
Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- A chromosome-level genome assembly of Platycladus orientalis and comparative genomics reveal pivotal roles of transposable elements in gene duplication and pseudogenization across gymnosperm giga-genomes.Plant communications · 2026Article
- Genome size estimation and evolution trends in Acari.Experimental & applied acarology · 2025Article
- Systematic identification of cargo-mobilizing genetic elements reveals new dimensions of eukaryotic diversity.Nucleic acids research · 2024Article
- Tracking the Diversity and Chromosomal Distribution of the Olfactory Receptor Gene Repertoires of Three Anurans Species.Journal of molecular evolution · 2023Article
- Strong, Recent Selective Sweeps Reshape Genetic Diversity in Freshwater Bivalve Megalonaias nervosa.Molecular biology and evolution · 2023Article
- Gene fusion as an important mechanism to generate new genes in the genus Oryza.Genome biology · 2022Article
- Repeated translocation of a supergene underlying rapid sex chromosome turnover inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sequencing an F1 hybrid of Silurus asotus and S. meridionalis enabled the assembly of high-quality parental genomes.Scientific reports · 2021Article
- The genomic architecture and molecular evolution of ant odorant receptors.Genome research · 2018Article
- Evolution and Expression Divergence of E2 Gene Family under Multiple Abiotic and Phytohormones Stresses inBioMed research international · 2018Article
- Review
- Genome-wide identification and expression analysis of E2 ubiquitin-conjugating enzymes in tomato.Scientific reports · 2017Article
- Chimeras Linked to Tandem Repeats and Transposable Elements in Tetraploid Hybrid Fish.Marine biotechnology (New York, N.Y.) · 2017Article
- Silencing of Transposable Elements by piRNAs in Drosophila: An Evolutionary Perspective.Genomics, proteomics & bioinformatics · 2017Review
- The impact and origin of copy number variations in the Oryza species.BMC genomics · 2016Article
- Genome-Wide Identification, Phylogenetic and Expression Analyses of the Ubiquitin-Conjugating Enzyme Gene Family in Maize.PloS one · 2015Article
- Rolling-circle transposons catalyze genomic innovation in a mammalian lineage.Genome biology and evolution · 2014Article
- Constraint and opportunity in genome innovation.RNA biology · 2014Review
- Molecular evolution of the porcine type I interferon family: subtype-specific expression and antiviral activity.PloS one · 2014Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
Previous studies of repetitive elements (REs) have implicated a mechanistic role in generating new chimerical genes. Such examples are consistent with the classic model for exon shuffling, which relies on non-homologous recombination. However, recent data for chromosomal aberrations in model organisms suggest that ectopic homology-dependent recombination may also be important. Lack of a dataset comprising experimentally verified young duplicates has hampered an effective examination of these models as well as an investigation of sequence features that mediate the rearrangements. Here we use approximately 7,000 cDNA probes (approximately 112,000 primary images) to screen eight species within the Drosophila melanogaster subgroup and identify 17 duplicates that were generated through ectopic recombination within the last 12 mys. Most of these are functional and have evolved divergent expression patterns and novel chimeric structures. Examination of their flanking sequences revealed an excess of repetitive sequences, with the majority belonging to the transposable element DNAREP1 family, associated with the new genes. Our dataset strongly suggests an important role for REs in the generation of chimeric genes within these species.
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