ArticlePLoS genetics2008
Discerning the ancestry of European Americans in genetic association studies.
Article in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 11 of them syntheses that pooled it.
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Who cites it
214 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- An integrated analysis of the association between Ts gene polymorphisms and clinical outcome in gastric and colorectal cancer patients treated with 5-FU-based regimens.Molecular biology reports · 2013Pooled it
- Evaluating reported candidate gene associations with polycystic ovary syndrome.Fertility and sterility · 2013Pooled it
- Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals.Human molecular genetics · 2013Pooled it
- Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.American journal of human genetics · 2012Pooled it
- Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis.Arthritis and rheumatism · 2012Pooled it
- PTPN22 C1858T and the risk of psoriasis: a meta-analysis.Molecular biology reports · 2012Pooled it
- A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.Circulation. Cardiovascular genetics · 2012Pooled it
- Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.American journal of human genetics · 2012Pooled it
- The MYH9/APOL1 region and chronic kidney disease in European-Americans.Human molecular genetics · 2011Pooled it
- Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.PLoS genetics · 2011Pooled it
- Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.American journal of human genetics · 2011Pooled it
- Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype.The Journal of allergy and clinical immunology · 2020Trial
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- Genomic Landscape of Breast Cancer: Study Across Diverse Ethnic Groups.Diseases (Basel, Switzerland) · 2025Article
- Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.Biology of sex differences · 2024Article
- Regional European genetic ancestry predicts type I interferon level and risk of severe viral infection.QJM : monthly journal of the Association of Physicians · 2024Article
- Variations in Genetic Diversity of Invasive SpeciesAnimals : an open access journal from MDPI · 2024Article
- A comprehensive analysis of clinical and polygenic germline influences on somatic mutational burden.American journal of human genetics · 2024Article
154 more citing papers are in PubMed but not listed here.
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20 authors.
Funding
Abstract
European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease risk differs across European ancestries. Here, we investigate empirical patterns of population structure in European Americans, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure. Building on this insight, we constructed a panel of 300 validated markers that are highly informative for distinguishing these ancestries. We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.