Evidence map›Paper›PMID 18206807›Full record

ReviewTrends in cardiovascular medicine2008

Endothelial progenitor cells for cardiovascular regeneration.

Atsuhiko Kawamoto, Douglas W Losordo

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 104 citations in OpenAlex.

  1. Cardiac preservation usingFrontiers in cardiovascular medicine · 2025
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  11. Acarbose Accelerates Wound Healing via Akt/eNOS Signaling inOxidative medicine and cellular longevity · 2017
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Atsuhiko KawamotoVascular Regeneration Research Group, Institute of Biomedical Research and Innovation, Kobe, Japan.
Douglas W Losordo
Northwestern University · USRIKEN Center for Computational Science · JP

Funding

RE-ENDOTHELIALIZATION AND RESTENOSIS IIR01HL057516 · NHLBI · STEWARD ST. ELIZABETH'S MEDICAL CENTER · PI LOSORDO, DOUGLAS W · 1997 to 2008
$3.3M
RESTENOSIS AND ENDOTHELIAL PROLIFERATIONR01HL063414 · NHLBI · STEWARD ST. ELIZABETH'S MEDICAL CENTER · PI LOSORDO, DOUGLAS W · 1999 to 2007
$2.5M
Autologous CD34+ Cell Therapy for Therapeutic Angiogenesis in Advanced PADR01HL077428 · NHLBI · STEWARD ST. ELIZABETH'S MEDICAL CENTER · PI LOSORDO, DOUGLAS W · 2006 to 2011
$2.5M
Role of Progenitor Cells in Cardiovascular MedicineR01HL080137 · NHLBI · STEWARD ST. ELIZABETH'S MEDICAL CENTER · PI LOSORDO, DOUGLAS W · 2006 to 2010
$1.9M
NHLBI NIH HHS R01 HL057516NHLBI NIH HHS R01 HL063414NHLBI NIH HHS R01 HL077428NHLBI NIH HHS R01 HL080137
6 · The paper itself

Abstract

Endothelial progenitor cells (EPCs) are peripheral blood mononuclear cells that can differentiate into mature endothelial cells. Adult EPCs were first discovered in human peripheral blood in 1997. Since then, the potency of EPCs for cardiovascular regeneration has been demonstrated in several preclinical studies; and investigators are beginning to evaluate the therapeutic utility of EPCs in early-phase clinical trials. This review summarizes the progression of basic, preclinical, and clinical research into the potential use of EPC therapy for cardiovascular regeneration.

Indexed as

AnimalsBone Marrow CellsCardiovascular DiseasesCell Culture TechniquesEndothelium, VascularHumansNeovascularization, PhysiologicRegenerationStem CellsStem Cell Transplantation

Identifiers

PMID18206807
PMCPMC2276734
OpenAlexW1963969874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.