ReviewNeuropsychologia2008
Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies.
Review in Neuropsychologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
175 citing papers in PubMed, 4 syntheses or guidelines pooled it, 374 citations in OpenAlex.
- Perfusion-weighted MRI patterns in neuropsychiatric systemic lupus erythematosus: a systematic review and meta-analysis.Neuroradiology · 2025Pooled it
- Transcranial Direct Current Stimulation (tDCS) as a Useful Rehabilitation Strategy to Improve Cognition in Patients With Alzheimer's Disease and Parkinson's Disease: An Updated Systematic Review of Randomized Controlled Trials.Frontiers in neurology · 2021Pooled it
- Magnetic resonance imaging for assessment of cerebrovascular reactivity and its relationship to cognition: a systematic review.BMC neuroscience · 2018Pooled it
- Pooled it
- Mnemonic strategy training increases neocortical activation in healthy older adults and patients with mild cognitive impairment.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Trial
- Differential Effects of BMI on Brain Response to Odor in Olfactory, Reward and Memory Regions: Evidence from fMRI.Nutrients · 2019Trial
- Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI.PloS one · 2018Trial
- Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI).The international journal of neuropsychopharmacology · 2017Trial
- Cholinergic enhancement of functional networks in older adults with mild cognitive impairment.Annals of neurology · 2013Trial
- Reduced frontal activation during a working memory task in mild cognitive impairment: a non-invasive near-infrared spectroscopy study.CNS neuroscience & therapeutics · 2013Trial
- Mnemonic strategy training partially restores hippocampal activity in patients with mild cognitive impairment.Hippocampus · 2012Trial
- Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study.Journal of Alzheimer's disease : JAD · 2011Trial
- Cognitive heterogeneity in mild cognitive impairment due to Alzheimer's disease pathology.Neural regeneration research · 2026Article
- Qualitative Analysis of Constructional Errors in Neurodegenerative Conditions: A Systematic Review.Brain sciences · 2026Review
- ABCA7 rs115550680 risk allele carriers have lower medial temporal lobe dynamic network flexibility than APOE-ε4 allele carriers among older African Americans.Neurobiology of aging · 2026Article
- Elevated plasma sex hormone-binding globulin (SHBG) is associated with reduced temporal lobe volume and cognitive impairment in individuals with mild cognitive impairment.European geriatric medicine · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Impaired event-related theta spectral coherence in emotional facial expression processing in neurodegenerative disorders.Frontiers in human neuroscience · 2026Article
- Decoding memory function through naturalistic gaze patterns.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Compensatory cerebellar activation during fluid intelligence processing following mild traumatic brain injury.Scientific reports · 2025Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Functional MRI (fMRI) studies of mild cognitive impairment (MCI) and Alzheimer's disease (AD) have begun to reveal abnormalities in memory circuit function in humans suffering from memory disorders. Since the medial temporal lobe (MTL) memory system is a site of very early pathology in AD, a number of studies, reviewed here, have focused on this region of the brain. By the time individuals are diagnosed clinically with AD dementia, the substantial memory impairments appear to be associated with not only MTL atrophy but also hypoactivation during memory task performance. Prior to dementia, when individuals are beginning to manifest signs and symptoms of memory impairment, the hippocampal formation and other components of the MTL memory system exhibit substantial functional abnormalities during memory task performance. It appears that, early in the course of MCI when memory deficits and hippocampal atrophy are less prominent, there may be hyperactivation of MTL circuits, possibly representing inefficient compensatory activity. Later in the course of MCI, when considerable memory deficits are present, MTL regions are no longer able to activate during attempted learning, as is the case in AD dementia. Recent fMRI data in MCI and AD are beginning to reveal relationships between abnormalities of functional activity in the MTL memory system and in functionally connected brain regions, such as the precuneus. As this work continues to mature, it will likely contribute to our understanding of fundamental memory processes in the human brain and how these are perturbed in memory disorders. We hope these insights will translate into the incorporation of measures of task-related brain function into diagnostic assessment or therapeutic monitoring, such as for use in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.