ArticleHormones and behavior2008
Opposing actions of 5HT1A and 5HT2-like serotonin receptors on modulations of the electric signal waveform in the electric fish Brachyhypopomus pinnicaudatus.
Article in Hormones and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior.Frontiers in neural circuits · 2021Review
- Encoding and Perception of Electro-communication Signals inFrontiers in integrative neuroscience · 2019Review
- Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.Neuroscience · 2014Article
- Neuromodulation of early electrosensory processing in gymnotiform weakly electric fish.The Journal of experimental biology · 2013Review
- Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects.Genes, brain, and behavior · 2012Article
- Differential serotonergic modulation of two types of aggression in weakly electric fish.Frontiers in behavioral neuroscience · 2012Article
- Androgens enhance plasticity of an electric communication signal in female knifefish, Brachyhypopomus pinnicaudatus.Hormones and behavior · 2009Article
- Melanocortins regulate the electric waveforms of gymnotiform electric fish.Hormones and behavior · 2009Article
- Signal Cloaking by Electric Fish.BioscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their effects on EOD amplitude and duration. We present evidence that two sets of serotonin receptors modulate the EOD in opposite directions. We found that the 5HT1AR agonist 8-OH-DPAT diminishes EOD duration and amplitude while the 5HT1AR antagonist WAY100635 increases these parameters. In contrast, the 5HT2R agonist alpha-Me-5-HT increases EOD amplitude but not duration, yet 5-HT-induced increases in EOD duration can be inhibited by blocking 5HT2A/2C-like receptors with ketanserin. These results show that 5-HT exerts bi-directional control of EOD modulations in B. pinnicaudatus via action at receptors similar to mammalian 5HT1A and 5HT2 receptors. The discordant amplitude and duration response suggests separate mechanisms for modulating these waveform parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.