SynthesisBreast cancer research : BCR2008
Intrauterine environments and breast cancer risk: meta-analysis and systematic review.
Synthesis in Breast cancer research : BCR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Adverse pregnancy outcomes and multiple cancers risk in both mother and offspring: an umbrella review of systematic reviews with meta-analyses of observational studies.BMC medicine · 2024Pooled it
- Association of birth weight with cancer risk: a dose-response meta-analysis and Mendelian randomization study.Journal of cancer research and clinical oncology · 2023Pooled it
- Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review.BMC pregnancy and childbirth · 2021Pooled it
- Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review.Reproductive toxicology (Elmsford, N.Y.) · 2016Pooled it
- Birth weight and adult cancer incidence: large prospective study and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2014Pooled it
- Association of high birth weight with risk of early-onset colorectal cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Nutrition Across the Life Course and Risk of Young-Onset Breast Cancer: Mechanisms, Evidence, and Prevention Opportunities.Nutrients · 2026Review
- Review
- Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis.Cancer reports (Hoboken, N.J.) · 2022Review
- Epidemiology beyond its limits.Science advances · 2022Article
- Perinatal factors, female breast cancer, and associated risk factors in Puerto Rico: evidence from the Atabey epidemiology of breast cancer study.Cancer causes & control : CCC · 2022Article
- Neonatal Birth Weight of the Woman as a Risk Factor for Breast Cancer in her Life: a Case-Control Bicentric Study.Materia socio-medica · 2021Article
- The association of women's birth size with risk of molecular breast cancer subtypes: a cohort study.BMC cancer · 2021Article
- Perinatal and postnatal exposures and risk of young-onset breast cancer.Breast cancer research : BCR · 2020Article
- Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline.Frontiers in nutrition · 2020Review
- The Relationship of Pre and Early Postnatal Risk Factors with Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Do Birth Weight and Weight Gain During Infancy and Early Childhood Explain Variation in Mammographic Density in Women in Midlife? Results From Cohort and Sibling Analyses.American journal of epidemiology · 2019Article
- Breast cancer and exposure to tobacco smoke during potential windows of susceptibility.Cancer causes & control : CCC · 2017Article
- Article
- Opportunities During Early Life for Cancer Prevention: Highlights From a Series of Virtual Meetings With Experts.Pediatrics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionVarious perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal environment of the developing fetal mammary glands. Despite ample biologic plausibility, epidemiologic studies to date have yielded conflicting results. We investigated the associations between perinatal factors and subsequent breast cancer risk through meta-analyses.
methodsWe reviewed breast cancer studies published from January 1966 to February 2007 that included data on birth weight, birth order, maternal age, gestational age, twin status, and maternal or paternal smoking. Meta-analyses using random effect models were employed to summarize the results.
resultsWe found that heavier birth weights were associated with increased breast cancer risk, with studies involving five categories of birth weight identifying odds ratios (ORs) of 1.24 (95% confidence interval [CI] 1.04 to 1.48) for 4,000 g or more and 1.15 (95% CI 1.04 to 1.26) for 3,500 g to 3,999 g, relative to a birth weight of 2,500 to 2,599 g. These studies provided no support for a J-shaped relationship of birthweight to risk. Support for an association with birthweight was also derived from studies based on three birth weight categories (OR 1.15 [95% CI 1.01 to 1.31] for > or =4,000 g relative to <3,000 g) and two birth weight categories (OR 1.09 [95% CI 1.02 to 1.18] for > or =3,000 g relative to <3,000 g). Women born to older mothers and twins were also at some increased risk, but the results were heterogeneous across studies and publication years. Birth order, prematurity, and maternal smoking were unrelated to breast cancer risk.
conclusionOur findings provide some support for the hypothesis that in utero exposures reflective of higher endogenous hormone levels could affect risk for development of breast cancer in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.