ArticleRheumatology international2008
Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis: comparison with rheumatoid arthritis patients and healthy controls.
Article in Rheumatology international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Systemic inflammatory biomarkers are novel predictors of all-cause and cardiovascular mortality in individuals with osteoarthritis: a prospective cohort study using data from the NHANES.BMC public health · 2024Article
- Update on recent developments in imaging of inflammation in osteoarthritis: a narrative review.Skeletal radiology · 2023Review
- Identification of autophagy-related genes in osteoarthritis articular cartilage and their roles in immune infiltration.Frontiers in immunology · 2023Article
- Expanded CD1cJournal of immunology research · 2022Article
- Immunofluorescence Analysis of NF-kB and iNOS Expression in Different Cell Populations during Early and Advanced Knee Osteoarthritis.International journal of molecular sciences · 2021Article
- A Novel Autophagy-Related Marker for Improved Differential Diagnosis of Rheumatoid Arthritis and Osteoarthritis.Frontiers in genetics · 2021Article
- Article
- A predominant Th1 polarization is present in synovial fluid of end-stage osteoarthritic knee joints: analysis of peripheral blood, synovial fluid and synovial membrane.Clinical and experimental immunology · 2019Article
- Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.Human gene therapy. Clinical development · 2018Article
- Icariin Regulates Cellular Functions and Gene Expression of Osteoarthritis Patient-Derived Human Fibroblast-Like Synoviocytes.International journal of molecular sciences · 2017Article
- Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint.Scientific reports · 2017Article
- Early changes in the knee of healer and non-healer mice following non-invasive mechanical injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- T Cells in Osteoarthritis: Alterations and Beyond.Frontiers in immunology · 2017Review
- Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Subchondral Bone and Similarity to Overlying Cartilage.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Is CD69 an effective brake to control inflammatory diseases?Trends in molecular medicine · 2013Review
- Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.Therapeutic advances in musculoskeletal disease · 2012Article
- Diagnosis of osteoarthritis: imaging.Bone · 2012Review
- Anticytokine therapy for osteoarthritis: evidence to date.Drugs & aging · 2010Article
- Developments in the scientific understanding of osteoarthritis.Arthritis research & therapy · 2009Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis (OA) is largely considered to be a non-inflammatory disease, although there is compelling evidence that subclinical inflammation is a common event, even in the absence of acute inflammatory flares. In this study we analyze, by means of CD5 and CD69 expression, the infiltration and early activation of CD5+cells, mostly lymphocytes, in both synovial membrane and synovial fluid from advanced OA patients and compare them with samples from patients with rheumatoid arthritis and healthy controls. The number of infiltrating CD5+ cells in both synovial membrane and synovial fluid from patients with advanced OA was significantly reduced as compared with rheumatoid arthritis patients. However, synovial membrane and synovial fluid CD5+ cells on OA exhibited a phenotype with evidence of recent activation comparable to that observed in RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.