Evidence map›Paper›PMID 18204940›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2008

Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S.

David H Henry, Hema N Viswanathan, Eric P Elkin, Shana Traina, Shawn Wade, David Cella

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 194 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 16 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03249090 nacompletednot on this mapstarted 2017, after this paper: background citation

"PRO-TECT" Patient Reported Outcomes to Enhance Cancer Treatment

TypeinterventionalSponsorAlliance Foundation Trials, LLC.Ran2017 to 2023Enrolled1,197ConditionsMetastatic CancerArmsPatient Self-Reporting of Symptoms, Usual Care Delivery
NCT05425550 naterminatednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Medidux™ Digital Health Application in Patients With HER2-positive Breast Cancer During Chemotherapy in Combination With HER2-targeted Therapy (Including Tyrosine Kinase Inhibitors [TKI]) or an Antibody-drug Conjugate Therapy: a Multicenter Randomized Controlled Trial.

TypeinterventionalSponsorPalleos Healthcare GmbHRan2022 to 2025Enrolled196ConditionsBreast CancerArmsmedidux™ app
3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 16 syntheses or guidelines pooled it, 382 citations in OpenAlex.

  1. Pooled it
  2. Experiences of breast cancer survivors with exercise rehabilitation: qualitative systematic review and meta-synthesis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Ameliorative effects of Tai Chi on cancer-related fatigue: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Self-management education interventions for patients with cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
  11. Pooled it
  12. Cancer-Related Fatigue, Version 2.2015.Journal of the National Comprehensive Cancer Network : JNCCN · 2015
    Guideline
  13. Survivorship: fatigue, version 1.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014
    Guideline
  14. Pooled it
  15. Emergency department visits for symptoms experienced by oncology patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012
    Pooled it
  16. Pooled it
  17. Impact of a Functional Intervention with Home Follow-Up on Respiratory Symptoms and Functionality in Oncology Patients: A Randomised Clinical Trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  18. Trial
  19. Trial
  20. Trial

134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

David H HenryJoan Karnell Cancer Center, Pennsylvania Hospital, 230 W Washington Square, Philadelphia, PA, 19106, USA. dhhenry@juno.com
Hema N Viswanathan
Eric P Elkin
Shana Traina
Shawn Wade
David Cella
Amgen (United States) · USDesign Interactive (United States) · USNorthShore University HealthSystem · USPennsylvania Hospital · USPinnacle Clinical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

goalsTo examine the prevalence of chemotherapy-or radiotherapy-associated side effects and related treatment burden, and correlates of fatigue and missed work days among cancer patients. MATERIALS AND

methodsA cross-sectional survey was conducted using a dual sampling frame of 63,949 cancer patients (35,751 from an online panel and 28,198 from telephone listings) > or = 18 years receiving chemotherapy and/or radiotherapy at the time of the survey or during the previous 12 months. Data were collected on cancer type, time since diagnosis, treatment side effects, visits, caregiver burden, missed work days, and sociodemographic characteristics. Data are presented only for patients receiving cancer treatment at the time of the survey. MAIN

resultsOf the 15,532 patients (24%) who responded to the screening questionnaire, 1,572 met the eligibility criteria and 1,569 completed the survey; 814 received chemotherapy and/or radiotherapy at the time of the survey. The most common side effects were fatigue (80%), pain (48%), and nausea/vomiting (48%). Patients spent 4.5 h, on average, per visit to treat side effects. Approximately 43% of the patients were employed; of these, 78% were actively working. Employed patients missed, on average, 18 work days annually for side effect treatment. Females, younger and unemployed patients, and those with higher levels of anxiety and depression experienced more fatigue; patients with a greater number of side effects endured more missed work days.

conclusionsIn addition to the symptomatic experience of side effects, patients reported a considerable time burden for treatment. It is important to consider supportive care strategies that may effectively reduce side effects and their associated treatment burden.

Indexed as

Antineoplastic AgentsCross-Sectional StudiesFatigueFemaleHealth Status IndicatorsHumansMaleMiddle AgedNeoplasmsPrevalenceRadiotherapyRisk FactorsSurveys and QuestionnairesUnited StatesAntineoplastic Agents

Identifiers

PMID18204940
OpenAlexW1972479281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.