ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Platelet activation due to hemodynamic shear stresses: damage accumulation model and comparison to in vitro measurements.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 226 citations in OpenAlex.
- The Efficiency-Hemocompatibility Paradox: A Comparative Lagrangian and Eulerian Analysis of Micro-axial p-LVAD Architectures.Annals of biomedical engineering · 2026Article
- Circulating Endothelial-Associated Biomarker Responses During Beating-Heart Partial Versus Cardioplegic Total Cardiopulmonary Bypass in Juvenile Pigs: An Exploratory Comparative Study.Veterinary sciences · 2026Article
- Interpretable Machine Learning for Feature-Based Classification of Platelet Activation in Rotary Blood Pumps.Cardiovascular engineering and technology · 2026Article
- Computational fluid dynamics-based risk stratification of modified Blalock-Taussig-Thomas shunt thrombogenicity.The Journal of thoracic and cardiovascular surgery · 2026Article
- Platelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.Orphanet journal of rare diseases · 2026Article
- Higher blood flow rates in anticoagulation-free CRRT improve circuit survival and clinical outcome.Clinical kidney journal · 2026Article
- A patient-specific CTA-CFD framework deciphers hemodynamic heterogeneity after fenestrated TEVAR: a pilot study.Frontiers in bioengineering and biotechnology · 2026Article
- 3D Membrane Microstructures for Increased Efficiency in Blood-Gas Transfer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A 2D computational model of chemically- and mechanically-induced platelet plug formation.Biomechanics and modeling in mechanobiology · 2025Article
- A Neural-Operator Surrogate for Platelet Deformation Across Capillary Numbers.Bioengineering (Basel, Switzerland) · 2025Article
- A silicon membrane microfluidic oxygenator for use as an artificial placenta with minimal anticoagulation.Bioengineering & translational medicine · 2025Article
- Venous thrombosis unchained: Pandora's box of noninflammatory mechanisms.Blood advances · 2025Review
- Influence of LVAD Cannula Outflow Graft Flow Rate and Location on Fluid-Particle Interactions and Thrombi Distribution: A Primary Numerical Study.Journal of cardiovascular translational research · 2024Article
- Manufacturing, Processing, and Characterization of Self-Expanding Metallic Stents: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2024Review
- A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis.Annals of biomedical engineering · 2024Article
- Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress.Artificial organs · 2024Article
- Shear Histories Alter Local Shear Effects on Thrombus Nucleation and Growth.Annals of biomedical engineering · 2024Article
- Thrombocytopenia Following Isolated Surgical Aortic Valve Replacement With Inspiris Resilia Bioprosthesis.Translational medicine @ UniSa · 2024Article
- Rethinking mechanical heart valves in the aortic position: new paradigms in design and testing.Frontiers in cardiovascular medicine · 2024Review
- Vibro-Acoustic Platelet Activation: An Additive Mechanism of Prothrombosis with Applicability to Snoring and Obstructive Sleep Apnea.Bioengineering (Basel, Switzerland) · 2023Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The need to optimize the thrombogenic performance of blood recirculating cardiovascular devices, e.g., prosthetic heart valves (PHV) and ventricular assist devices (VAD), is accentuated by the fact that most of them require lifelong anticoagulation therapy that does not eliminate the risk of thromboembolic complications. The formation of thromboemboli in the flow field of these devices is potentiated by contact with foreign surfaces and regional flow phenomena that stimulate blood clotting, especially platelets. With the lack of appropriate methodology, device manufacturers do not specifically optimize for thrombogenic performance. Such optimization can be facilitated by formulating a robust numerical methodology with predictive capabilities of flow-induced platelet activation. In this study, a phenomenological model for platelet cumulative damage, identified by means of genetic algorithms (GAs), was correlated with in vitro experiments conducted in a Hemodynamic Shearing Device (HSD). Platelets were uniformly exposed to flow shear representing the lower end of the stress levels encountered in devices, and platelet activity state (PAS) was measured in response to six dynamic shear stress waveforms representing repeated passages through a device, and correlated to the predictions of the damage accumulation model. Experimental results demonstrated an increase in PAS with a decrease in "relaxation" time between pulses. The model predictions were in very good agreement with the experimental results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.