ArticleApplied and environmental microbiology2008
Novel microarray design strategy to study complex bacterial communities.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Measuring the Invisible: Microbial Diagnostics for Periodontitis-A Narrative Review.International journal of molecular sciences · 2025Review
- Analysis of Microbial Communities in Membrane Biofilm Reactors Using a High-Density Microarray.Membranes · 2023Article
- High-Density Microarray Analysis of Microbial Community Structures in Membrane Bioreactor at Short Sludge Retention Time.Membranes · 2023Article
- Host and bacterial factors linking periodontitis and rheumatoid arthritis.Frontiers in immunology · 2022Review
- GPR-Analyzer: a simple tool for quantitative analysis of hierarchical multispecies microarrays.Environmental science and pollution research international · 2013Article
- Microarray analysis of microbiota of gingival lesions in noma patients.PLoS neglected tropical diseases · 2013Article
- Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer.Gut · 2012Article
- Salivary biomarker development using genomic, proteomic and metabolomic approaches.Genome medicine · 2012Review
- Gut microbiota and inflammation.Nutrients · 2011Review
- New concepts in the evaluation of biodegradation/persistence of chemical substances using a microbial inoculum.Frontiers in microbiology · 2011Article
- The Extended Nutrigenomics - Understanding the Interplay between the Genomes of Food, Gut Microbes, and Human Host.Frontiers in genetics · 2011Article
- Study of inter- and intra-individual variations in the salivary microbiota.BMC genomics · 2010Article
- Community dynamics of bacteria in sourdough fermentations as revealed by their metatranscriptome.Applied and environmental microbiology · 2010Article
- Periodontitis: a polymicrobial disruption of host homeostasis.Nature reviews. Microbiology · 2010Review
- Metagenomic study of the oral microbiota by Illumina high-throughput sequencing.Journal of microbiological methods · 2009Article
- Characterization of microbial pathogens by DNA microarrays.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Distinctive features of the microbiota associated with different forms of apical periodontitis.Journal of oral microbiology · 2009Article
- High-throughput quantitative analysis of the human intestinal microbiota with a phylogenetic microarray.Applied and environmental microbiology · 2009Article
- Molecular microbial diagnosis.Periodontology 2000 · 2009Review
- Salivary biomarkers for clinical applications.Molecular diagnosis & therapy · 2009Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Assessing bacterial flora composition appears to be of increasing importance to fields as diverse as physiology, development, medicine, epidemiology, the environment, and the food industry. We report here the development and validation of an original microarray strategy that allows analysis of the phylogenic composition of complex bacterial mixtures. The microarray contains approximately 9,500 feature elements targeting 16S rRNA gene-specific regions. Probe design was performed by selecting oligonucleotide sequences specific to each node of the seven levels of the bacterial phylogenetic tree (domain, phylum, class, order, family, genus, and species). This approach, based on sequence information, allows analysis of the bacterial contents of complex bacterial mixtures to detect both known and unknown microorganisms. The presence of unknown organisms can be suspected and mapped on the phylogenetic tree, indicating where to refine analysis. Initial proof-of-concept experiments were performed on oral bacterial communities. Our results show that this hierarchical approach can reveal minor changes (<or=1%) in gingival flora content when samples collected in individuals from similar geographical origins are compared.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.