ArticleNucleic acids research2008
rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Evolution of a core ribosomal innovation in octopus.Current biology : CB · 2026Article
- Evolution of a core ribosomal innovation in octopus.bioRxiv : the preprint server for biology · 2026Article
- The role of ribosomal protein networks in ribosome dynamics.Nucleic acids research · 2025Article
- Sordarin bound eEF2 unlocks spontaneous forward and reverse translocation on CrPV IRES.Nucleic acids research · 2023Article
- Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome.Nucleic acids research · 2023Article
- Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021Review
- Context-specific action of macrolide antibiotics on the eukaryotic ribosome.Nature communications · 2021Article
- Evolution of ribosomal protein network architectures.Scientific reports · 2021Article
- A Structural Basis for Restricted Codon Recognition Mediated by 2-thiocytidine in tRNA Containing a Wobble Position Inosine.Journal of molecular biology · 2020Article
- Exploring allosteric communication in multiple states of the bacterial ribosome using residue network analysis.Turkish journal of biology = Turk biyoloji dergisi · 2018Article
- Tracking fluctuation hotspots on the yeast ribosome through the elongation cycle.Nucleic acids research · 2017Article
- The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome.Journal of molecular biology · 2016Article
- Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol.Nucleic acids research · 2014Article
- Eukaryotic rpL10 drives ribosomal rotation.Nucleic acids research · 2014Article
- Small interfering RNA-mediated translation repression alters ribosome sensitivity to inhibition by cycloheximide in Chlamydomonas reinhardtii.The Plant cell · 2013Article
- Random mutagenesis of yeast 25S rRNA identify bases critical for 60S subunit structural integrity and function.Translation (Austin, Tex.) · 2013Article
- 40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay.The EMBO journal · 2012Article
- The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity.Molecular genetics and genomics : MGG · 2011Article
- Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes.RNA (New York, N.Y.) · 2011Article
- An extensive network of information flow through the B1b/c intersubunit bridge of the yeast ribosome.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To ensure accurate and rapid protein synthesis, nearby and distantly located functional regions of the ribosome must dynamically communicate and coordinate with one another through a series of information exchange networks. The ribosome is approximately 2/3 rRNA and information should pass mostly through this medium. Here, two viable mutants located in the peptidyltransferase center (PTC) of yeast ribosomes were created using a yeast genetic system that enables stable production of ribosomes containing only mutant rRNAs. The specific mutants were C2820U (Escherichia coli C2452) and Psi2922C (E. coli U2554). Biochemical and genetic analyses of these mutants suggest that they may trap the PTC in the 'open' or aa-tRNA bound conformation, decreasing peptidyl-tRNA binding. We suggest that these structural changes are manifested at the biological level by affecting large ribosomal subunit biogenesis, ribosomal subunit joining during initiation, susceptibility/resistance to peptidyltransferase inhibitors, and the ability of ribosomes to properly decode termination codons. These studies also add to our understanding of how information is transmitted both locally and over long distances through allosteric networks of rRNA-rRNA and rRNA-protein interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.