ArticleCerebral cortex (New York, N.Y. : 1991)2008
Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Delta-opioid receptor-mediated neural protection and regeneration.Neural regeneration research · 2026Article
- Article
- Hypoxic/Ischemic Inflammation, MicroRNAs and δ-Opioid Receptors: Hypoxia/Ischemia-Sensitive Versus-Insensitive Organs.Frontiers in aging neuroscience · 2022Review
- δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia.Frontiers in immunology · 2020Review
- δ-Opioid Receptor-Nrf-2-Mediated Inhibition of Inflammatory Cytokines in Neonatal Hypoxic-Ischemic Encephalopathy.Molecular neurobiology · 2019Article
- The δ-Opioid Receptor Differentially Regulates MAPKs and Anti-inflammatory Cytokines in Rat Kidney Epithelial Cells Under Hypoxia.Frontiers in physiology · 2019Article
- Prolonged DADLE exposure epigenetically promotes Bcl-2 expression and elicits neuroprotection in primary rat cortical neurons via the PI3K/Akt/NF-κB pathway.Acta pharmacologica Sinica · 2018Article
- Attenuating Ischemic Disruption of KMolecular neurobiology · 2016Article
- δ-Opioid receptors up-regulate excitatory amino acid transporters in mouse astrocytes.British journal of pharmacology · 2014Article
- Non-pharmaceutical therapies for stroke: mechanisms and clinical implications.Progress in neurobiology · 2014Review
- Deep brain stimulation: are astrocytes a key driver behind the scene?CNS neuroscience & therapeutics · 2014Review
- Delta opioid receptors in brain function and diseases.Pharmacology & therapeutics · 2013Review
- Delta opioid receptor and its peptide: a receptor-ligand neuroprotection.International journal of molecular sciences · 2013Article
- Neuroprotection against hypoxia/ischemia: δ-opioid receptor-mediated cellular/molecular events.Cellular and molecular life sciences : CMLS · 2013Review
- δ-Opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat.PloS one · 2013Article
- δ-Opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia.PloS one · 2013Article
- From Acupuncture to Interaction between δ-Opioid Receptors and Na (+) Channels: A Potential Pathway to Inhibit Epileptic Hyperexcitability.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex.Experimental neurology · 2012Article
- Current research on opioid receptor function.Current drug targets · 2012Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We have recently found that in the mouse cortex, activation of delta-opioid receptor (DOR) attenuates the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation. This novel observation suggests that DOR may protect neurons from hypoxic/ischemic insults via the regulation of K(+) homeostasis because the disruption of K(+) homeostasis plays a critical role in neuronal injury under hypoxic/ischemic stress. The present study was performed to explore the ionic mechanism underlying the DOR-induced neuroprotection. Because anoxia causes Na(+) influx and thus stimulates K(+) leakage, we investigated whether DOR protects the cortex from anoxic K(+) derangement by targeting the Na(+)-based K(+) leakage. By using K(+)-sensitive microelectrodes in mouse cortical slices, we showed that 1) lowering Na(+) concentration and substituting with impermeable N-methyl-D-glucamine caused a concentration-dependent attenuation of anoxic K(+) derangement; 2) lowering Na(+) concentration by substituting with permeable Li(+) tended to potentiate the anoxic K(+) derangement; and 3) the DOR-induced protection against the anoxic K(+) responses was largely abolished by low-Na(+) perfusion irrespective of the substituted cation. We conclude that external Na(+) concentration greatly influences anoxic K(+) derangement and that DOR activation likely attenuates anoxic K(+) derangement induced by the Na(+)-activated mechanisms in the cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.