Evidence map›Paper›PMID 18203617›Full record

ReviewCytokine2008

Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system.

Shella Saint Fleur, Hodaka Fujii

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shella Saint FleurDepartment of Pathology, New York University School of Medicine, 550 First Avenue, MSB-126, New York, NY 10016, USA.
Hodaka Fujii
New York University · US

Funding

Cytokine signal transduction in immune systemR01AI059315 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FUJII, HODAKA · 2005 to 2007
$989k
NIAID NIH HHS R01 AI059315NIAID NIH HHS R01 AI059315.
6 · The paper itself

Abstract

Binding of cytokines to their specific receptors induces activation of signal transduction pathways, many of which involve nuclear translocation of signaling proteins. In this review, an overview of cytokine-induced nuclear translocation of signaling proteins is provided. In addition, inducible translocation trap (ITT), a novel reporter-based system to detect nuclear translocation, and its application for identification of nuclear translocating proteins are elaborated. Finally, analysis of "nuclear translocatome", the entire set of proteins that translocate into or out of the nucleus in response to extracellular stimuli, by ITT is discussed.

Indexed as

Genes, ReporterActive Transport, Cell NucleusAnimalsCell NucleusCytokinesGenetic TechniquesHumansIntracellular Signaling Peptides and ProteinsProtein TransportSignal TransductionSTAT Transcription FactorsCytokinesIntracellular Signaling Peptides and ProteinsSTAT Transcription Factors

Identifiers

PMID18203617
PMCPMC2289906
OpenAlexW2078069041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.