ArticleInternational journal of nanomedicine2007
PEGylation of nanoparticles improves their cytoplasmic transport.
Article in International journal of nanomedicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Copper Nanoparticles Enable Multi-Compartment Cuproenzyme Metalation in Cellular Models of Copper Deficiency.ACS chemical biology · 2026Article
- Elasticity promotes directional transport ofSoft matter · 2026Article
- Preparation of liposomal nanocarriers containing all-trans retinoic acid and docetaxel and their evaluation in a lung cancer cell line.Scientific reports · 2025Article
- Formulation and Characterization of Teicoplanin Niosomal Gel for Healing Chronic Wounds Infected with Methicillin-ResistantGels (Basel, Switzerland) · 2025Article
- Targeted gene therapy for cancer: the impact of microRNA multipotentiality.Medical oncology (Northwood, London, England) · 2024Review
- Targeted Nano-Based Systems for the Anti-Obesity Agent's Delivery.Advances in experimental medicine and biology · 2024Review
- Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges.Pharmaceutics · 2023Review
- Empowering Cancer Therapy: Comparing PEGylated and Non-PEGylated Niosomes Loaded with Curcumin and Doxorubicin on MCF-7 Cell Line.Bioengineering (Basel, Switzerland) · 2023Article
- Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model.Journal of otology · 2023Article
- 3D printing of nanocomposite pills through desktop vat photopolymerization (stereolithography) for drug delivery reasons.3D printing in medicine · 2022Article
- Human Laryngeal Mucus from the Vocal Folds: Rheological Characterization by Particle Tracking Microrheology and Oscillatory Shear Rheology.Applied sciences (Basel, Switzerland) · 2021Article
- The Synthesis Methodology of PEGylated FeMolecules (Basel, Switzerland) · 2021Article
- Taking Particle Tracking into Practice by Novel Software and Screening Approach: Case-Study of Oral Lipid Nanocarriers.Pharmaceutics · 2021Article
- Probing Intracellular Dynamics Using Fluorescent Carbon Dots Produced by Femtosecond LaserACS omega · 2020Article
- Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow.Bioengineering & translational medicine · 2020Article
- Gold nanoclusters elicit homeostatic perturbations in glioblastoma cells and adaptive changes of lysosomes.Theranostics · 2020Article
- Mucin CYS domain stiffens the mucus gel hindering bacteria and spermatozoa.Scientific reports · 2019Article
- Promises of Nanotherapeutics in Obesity.Trends in endocrinology and metabolism: TEM · 2019Review
- PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Classification and Segmentation of Nanoparticle Diffusion Trajectories in Cellular Micro Environments.PloS one · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The efficacy of nucleus-targeted drug- or gene-carrying nanoparticles may be limited by slow transport through the molecularly crowded cytoplasm following endosome escape. Cytoskeletal elements and cellular organelles may pose steric and/or adhesive obstacles to the efficient intracellular transport of nanoparticles. To potentially reduce adhesive interactions of colloids with intracellular components, the surface of model nanoparticles was coated with polyethylene glycol (PEG). Subsequently, multiple-particle tracking (MPT) was used to quantify the cytoplasmic transport rates of particles microinjected into the cytoplasm of live cells. PEGylation increased average nanoparticle diffusivities by 100% compared to unPEGylated particles (time scale of 10 s) in live cells. Faster particle transport correlated with a marked decrease in the number of particles that underwent hindered transport, from 79.2% (unmodified) to 48.8% (PEGylated). This result adds to an impressive list of positive benefits associated with PEGylation of drug and gene delivery vectors.
Indexed as
Identifiers
18203439PMC2676827What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.