Trial reportWorld journal of gastroenterology2008
Biliary brush cytology: factors associated with positive yields on biliary brush cytology.
Trial report in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative Diagnostic Accuracy of Cholangioscopy-Based Modalities for Indeterminate Biliary Strictures: A Systematic Review and Network Meta-Analysis.Digestive diseases and sciences · 2026Pooled it
- Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: the Papanicolaou Society of Cytopathology guidelines for pancreatobiliary cytology.Diagnostic cytopathology · 2014Guideline
- The Detection of Cholangiocarcinoma in Primary Sclerosing Cholangitis Patients: Single Center Experience.Journal of gastrointestinal cancer · 2016Trial
- Endoscopic Retrograde Cholangiopancreatography (ERCP) Brush-Based Cytology Vs Biopsy: a Comparative Diagnostic Study.Maedica · 2025Article
- The incidence and predictors of false-negative pancreatobiliary fluorescence in situ hybridization (PB-FISH) in biliary strictures: A prospective study.Hepatology communications · 2025Observational
- Yield of next-generation sequencing in diagnostic work up of suspicious biliary strictures.Endoscopy international open · 2025Article
- Enhancing diagnostic strategies for biliary strictures: an evolving landscape.Hepatobiliary surgery and nutrition · 2024Article
- National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma.World journal of gastroenterology · 2024Review
- High Diagnostic Yield of Endoscopic Retrograde Cholangiopancreatography Brush Cytology for Indeterminate Strictures.Journal of the Canadian Association of Gastroenterology · 2022Article
- Histological assessment of new cholangioscopy-guided forceps in ERCP biliary stricture sampling: a blinded comparative study.Endoscopy international open · 2022Article
- Accuracy of brush cytology in biliopancreatic strictures: a single-center cohort study.The Journal of international medical research · 2021Article
- An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran.Iranian journal of pathology · 2021Article
- Optimal tissue sampling during ERCP and emerging molecular techniques for the differentiation of benign and malignant biliary strictures.Therapeutic advances in gastroenterology · 2021Review
- Cholangioscopy Biopsies Improve Detection of Cholangiocarcinoma When Combined with Cytology and FISH, but Not in Patients with PSC.Digestive diseases and sciences · 2020Article
- Factors Associated with Malignant Biliary Strictures in Patients with Atypical or Suspicious Cells on Brush Cytology.Clinical endoscopy · 2019Article
- Investigation of Factors Affecting the Sensitivity of Bile Duct Brush Cytology.Internal medicine (Tokyo, Japan) · 2019Article
- Outcomes of Different Methods for Analysis of Biliary Brush Cytology and of Factors Associated with Positive Diagnosis in an Age-Dependent Retrospective Review.GE Portuguese journal of gastroenterology · 2018Article
- How to Brush Your Way into the Bile Duct.GE Portuguese journal of gastroenterology · 2018Article
- Comparison of liquid-based cytology (CellPrepPlus) and conventional smears in pancreaticobiliary disease.The Korean journal of internal medicine · 2018Article
- False negative and false positive rates in common bile duct brushing cytology, a single center experience.Gastroenterology and hepatology from bed to bench · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the yield of brushing biliary strictures and the factors associated with a positive result in biliary strictures.
methodsData on all consecutive patients (01/02-10/05) who were identified to have a biliary stricture and who underwent biliary brush cytology were collected. The yield of positive biliary brush cytology was evaluated and compared to results with the gold standard for diagnosis (defined as either definitive surgical histology or clinical course). Additionally, associated factors of positive results including stricture location, gender, age, mass size, length of stricture, and dilatation prior to brushing cytology were assessed.
resultsFrom 199 patients who had brushing cytology samples (10 patients were excluded due to lack of gold standard diagnosis), 77 patients had positive brushing cytology (yield 41%). Variables associated with positive cytology brushing on initial endoscopic retrograde cholangiography were age 1.02 (1.00-1.05), mass size>1 cm 2.22 (1.01-4.89) and length of stricture>1 cm 3.49 (1.18-10.2). The sensitivity of biliary brushing was 61%, its specificity 98%, the positive predictive value reached 99%, and the negative predictive value was 57%.
conclusionOur results revealed a 41% positive yield from brushing cytology. The sensitivity of biliary brushing cytology in our center was 61% and the specificity was 98%. Predictors of positive yield include older age, mass size>1 cm, and stricture length of >1 cm.
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