Evidence map›Paper›PMID 18202907›Full record

ReviewJournal of behavioral medicine2008

The impact of medication regimen factors on adherence to chronic treatment: a review of literature.

Karen S Ingersoll, Jessye Cohen

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of behavioral medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07555093 (A Randomized Controlled Trial in Lombok), which is not on this map. Cited by 215 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07555093 narecruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized Controlled Trial in Lombok: Assessing Factors Influencing Acceptance and Adherence to Multiple Micronutrient Supplementation (MMS) Using Digital Tools

TypeinterventionalSponsorSummit Institute for Development, IndonesiaRan2026 to 2027Enrolled10,012ConditionsPregnancy, AdherenceArmsBottle pack, Blister pack, Standard Care, Digital care
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  11. Association of medication adherence with treatment preferences: incentivizing truthful self-reporting.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Karen S IngersollDepartment of Psychiatry and Neurobehavioral Science, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA. kareningersoll@gmail.com
Jessye Cohen

Funding

Development of CART for HIV adherence and cocaine abuseR01DA016554 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI INGERSOLL, KAREN S · 2003 to 2006
$1.5M
HIV ADHERENCE MENTORED RES. SCIENTIST DEV. AWARDK01MH001688 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI INGERSOLL, KAREN S · 1999 to 2003
$473k
NIDA NIH HHS R01 DA 016554NIDA NIH HHS R01 DA016554NIMH NIH HHS K01 MH001688NIMH NIH HHS K01 MH01688
6 · The paper itself

Abstract

This article reviews recent literature in chronic illness or long-term health management including asthma, contraception, diabetes, HIV disease, and hypertension/cardiovascular disease, mental disorders, pain, and other diseases to determine the relationship between regimen factors and adherence to medications. The authors conducted an electronic literature search to detect articles published between 1998 and 2007. Articles were included if they pertained to a chronic illness or to contraception, included a clear definition of how adherence was measured, and included regimen factors as primary or secondary explanatory variables. Methodology of the studies varied greatly, as did methods of measuring adherence and regimen factors. Surprisingly few of these articles concerned (1) chronic treatment, (2) regimen factors such as dosing, pill burden, and regimen complexity, and (3) adherence measured in a clear manner. Most studies failed to use state-of-the-art methods of measuring adherence. Despite these flaws, a suggestive pattern of the importance of regimen factors, specifically dose frequency and regimen complexity, emerged from this review.

Indexed as

Acquired Immunodeficiency SyndromeAnti-HIV AgentsChronic DiseaseContraception BehaviorCost of IllnessDose-Response Relationship, DrugDrug Administration RoutesDrug Administration ScheduleHIV InfectionsHumansMotivationPatient ComplianceAnti-HIV Agents

Identifiers

PMID18202907
PMCPMC2868342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.