ArticleGenetics2008
Genetic design and statistical power of nested association mapping in maize.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 468 papers, 1 of them a synthesis that pooled it.
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Who cites it
468 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta genetic analysis of melon sweetness.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Pooled it
- An IRAT109 NAM population: Genetic characterization and mapping utility for trait dissection in japonica rice (Oryza sativa L.).The plant genome · 2026Article
- Feasibility and pitfalls of combining small subpopulations for genome-wide association analysis of maize (Zea mays L.) kernel traits.The plant genome · 2026Article
- Multi-isolate GWAS identifies broad-spectrum and isolate-specific resistance-associated loci for Septoria tritici blotch in synthetic hexaploid wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Evaluation of Maize Genotypes for Northern Leaf Blight Resistance and Yield in Ethiopian Hotspots.Plant-environment interactions (Hoboken, N.J.) · 2026Article
- NAM-BSA: A Bulked Segregant Analysis Method Using a NAM Population.Plants (Basel, Switzerland) · 2026Article
- Candidate genes for stem rust resistance in Italian ryegrass revealed by nested association mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Comparative transcriptome analysis to reveal key drought stress-responsive genes in sorghum (Sorghum bicolor (L.) Moench).BMC genomics · 2026Article
- Korean Soybean Nested Association Mapping (K-SoyNAM) population: genetic linkage map, genetic mapping, and genotype imputation.BMC genomics · 2026Article
- Marker-trait association analysis revealed loci linked to salinity tolerance in a worldwide collection of safflower.Scientific reports · 2026Article
- Three-dimensional infection network analysis in maize reveals variation in fungal colonization associated with lesion phenotypes.Scientific reports · 2026Article
- Article
- Unlocking salt tolerance from Fertile Crescent wild barley: evolutionary and physiological mechanisms in introgressed lines.Scientific reports · 2026Article
- Association mapping of hybrid seed set and heterosis in a central European multi-parental wheat population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- MaizeGDB Phylostrata Tool: exploring evolutionary origins of maize proteins.Bioinformatics advances · 2026Article
- Novel perpetual genetic population development and genome assembly of superior maize inbred lines provide insights into genetic improvement.BMC biology · 2025Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Nested association mapping in oat (Avena sativa L.) identifies the location of multiple genes conferring resistance to the crown rust pathogen Puccinia coronata f. sp. avenae.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A multifunctional sesquiterpene synthase integrates with cytochrome P450s to reinforce the terpenoid defense network in maize.The Plant journal : for cell and molecular biology · 2025Article
- Enhancing salinity tolerance in barley: harnessing introgressed nested genomes from the wild ancestor Hordeum spontaneum.BMC plant biology · 2025Article
408 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the genetic and statistical properties of the nested association mapping (NAM) design currently being implemented in maize (26 diverse founders and 5000 distinct immortal genotypes) to dissect the genetic basis of complex quantitative traits. The NAM design simultaneously exploits the advantages of both linkage analysis and association mapping. We demonstrated the power of NAM for high-power cost-effective genome scans through computer simulations based on empirical marker data and simulated traits with different complexities. With common-parent-specific (CPS) markers genotyped for the founders and the progenies, the inheritance of chromosome segments nested within two adjacent CPS markers was inferred through linkage. Genotyping the founders with additional high-density markers enabled the projection of genetic information, capturing linkage disequilibrium information, from founders to progenies. With 5000 genotypes, 30-79% of the simulated quantitative trait loci (QTL) were precisely identified. By integrating genetic design, natural diversity, and genomics technologies, this new complex trait dissection strategy should greatly facilitate endeavors to link molecular variation with phenotypic variation for various complex traits.
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