ArticleGenetics2008
Molecular population genetics of Drosophila subtelomeric DNA.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Paralogs of thebioRxiv : the preprint server for biology · 2026Article
- Telomerase-independent survival leads to a mosaic of complex subtelomere rearrangements inGenome research · 2023Article
- Architecture and evolution of subtelomeres in the unicellular green alga Chlamydomonas reinhardtii.Nucleic acids research · 2021Article
- Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere ofFrontiers in cell and developmental biology · 2021Review
- Identification and Characterization of Breakpoints and Mutations onG3 (Bethesda, Md.) · 2020Article
- Sequence analysis of wheat subtelomeres reveals a high polymorphism among homoeologous chromosomes.The plant genome · 2020Article
- Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Journal of molecular biology · 2020Review
- The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins.Trends in genetics : TIG · 2020Review
- Altered Localization of Hybrid Incompatibility Proteins in Drosophila.Molecular biology and evolution · 2019Article
- Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans.PLoS genetics · 2018Article
- The Molecular and Genetic Characterization of Second Chromosome Balancers inG3 (Bethesda, Md.) · 2018Article
- Short and long-term evolutionary dynamics of subtelomeric piRNA clusters in Drosophila.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Contrasting evolutionary genome dynamics between domesticated and wild yeasts.Nature genetics · 2017Article
- Article
- Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila.Molecular biology and evolution · 2017Article
- Targeted identification of TE insertions in aMobile DNA · 2017Article
- Article
- Sperm should evolve to make female meiosis fair.Evolution; international journal of organic evolution · 2015Article
- The relation between recombination rate and patterns of molecular evolution and variation in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- Identification of two Penelope-like elements with different structures and chromosome localization in kuruma shrimp genome.Marine biotechnology (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
DNA sequence surveys in yeast and humans suggest that the forces shaping telomeric polymorphism and divergence are distinctly more dynamic than those in the euchromatic, gene-rich regions of the chromosomes. However, the generality of this pattern across outbreeding, multicellular eukaryotes has not been determined. To characterize the structure and evolution of Drosophila telomeres, we collected and analyzed molecular population genetics data from the X chromosome subtelomere in 58 lines of North American Drosophila melanogaster and 29 lines of African D. melanogaster. We found that Drosophila subtelomeres exhibit high levels of both structural and substitutional polymorphism relative to linked euchromatic regions. We also observed strikingly different patterns of variation in the North American and African samples. Moreover, our analyses of the polymorphism data identify a localized hotspot of recombination in the most-distal portion of the X subtelomere. While the levels of polymorphism decline sharply and in parallel with rates of crossing over per physical length over the distal first euchromatic megabase pairs of the X chromosome, our data suggest that they rise again sharply in the subtelomeric region (approximately 80 kbp). These patterns of historical recombination and geographic differentiation indicate that, similar to yeast and humans, Drosophila subtelomeric DNA is evolving very differently from euchromatic DNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.