ArticleGenetics2008
A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
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- Naturally segregating genetic variants contribute to thermal tolerance in a Drosophila melanogaster model system.Genetics · 2024Article
- A novel insertional allele of theFrontiers in genetics · 2024Article
- The evolution of larger size in high-altitude Drosophila melanogaster has a variable genetic architecture.G3 (Bethesda, Md.) · 2022Article
- Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters.G3 (Bethesda, Md.) · 2021Article
- Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes.G3 (Bethesda, Md.) · 2021Article
- Analysis of insect nuclear small heat shock proteins and interacting proteins.Cell stress & chaperones · 2021Article
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- Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells.Nature communications · 2018Article
- Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA.Genetics · 2013Article
- A targeted genetic modifier screen links the SWI2/SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster.G3 (Bethesda, Md.) · 2013Article
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- The MYST-containing protein Chameau is required for proper sensory organ specification during Drosophila thorax morphogenesis.PloS one · 2012Article
- Exploiting Drosophila genetics to understand microRNA function and regulation.Current topics in developmental biology · 2012Review
- Establishment and maintenance of compartmental boundaries: role of contractile actomyosin barriers.Cellular and molecular life sciences : CMLS · 2011Review
- Polycomb preferentially targets stalled promoters of coding and noncoding transcripts.Genome research · 2011Article
- Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila wing primordium is subdivided into a dorsal (D) and a ventral (V) compartment by the activity of the LIM-homeodomain protein Apterous in D cells. Cell interactions between D and V cells induce the activation of Notch at the DV boundary. Notch is required for the maintenance of the compartment boundary and the growth of the wing primordium. Beadex, a gain-of-function allele of dLMO, results in increased levels of dLMO protein, which interferes with the activity of Apterous and results in defects in DV axis formation. We performed a gain-of-function enhancer-promoter (EP) screen to search for suppressors of Beadex when overexpressed in D cells. We identified 53 lines corresponding to 35 genes. Loci encoding for micro-RNAs and proteins involved in chromatin organization, transcriptional control, and vesicle trafficking were characterized in the context of dLMO activity and DV boundary formation. Our results indicate that a gain-of-function genetic screen in a sensitized background, as opposed to classical loss-of-function-based screenings, is a very efficient way to identify redundant genes involved in a developmental process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.