ArticleGenetics2008
rosy Function is required for juvenile hormone effects in Drosophila melanogaster.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Effect of a novel juvenoid fenoxycarb on the pupal-adult transformation in the blowfly, Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae).Parasitology research · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- Analysis of molecular mechanism for acceleration of polyembryony using gene functional annotation pipeline in Copidosoma floridanum.BMC genomics · 2020Article
- Targeted renal knockdown of NaAmerican journal of physiology. Renal physiology · 2019Article
- Characterization of xanthine dehydrogenase and aldehyde oxidase of Marsupenaeus japonicus and their response to microbial pathogen.Molecular biology reports · 2018Article
- Transcriptional responses of ecologically diverse Drosophila species to larval diets differing in relative sugar and protein ratios.PloS one · 2017Article
- Juvenile hormone regulation of Drosophila aging.BMC biology · 2013Article
- takeout-dependent longevity is associated with altered Juvenile Hormone signaling.Mechanisms of ageing and developmentArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Application of a high dose of juvenile hormone (JH) III or its mimics (JHM) to Drosophila at the white puparium stage causes the formation of a pupal-like abdomen with few or no short bristles. We report here that the rosy (ry) gene encoding the enzyme xanthine dehydrogenase (XDH), which catalyzes the final two-step oxidation in purine catabolism, is required for this effect of JH on the epidermis. In ry506 (null allele) homozygotes or hemizygotes, JH III or pyriproxifen (a JHM) had little effect on abdominal bristle or cuticle formation, but disrupted the development of the central nervous system as in wild-type flies. Wild-type ry rescued the JH sensitivity of the abdominal epidermis in ry506 mutants. Inhibition of XDH activity phenocopied the ry null mutant's insensitivity to JH. Larvae fed on hypoxanthine or xanthine showed a decreased JH sensitivity. ry506 clones were sensitive to JH, indicating that ry is required non-cell autonomously for the JH effects. Normally JH applied at pupariation causes the aberrant reexpression of the transcription factor broad in the abdominal epidermis during adult development, but in the ry506 mutant most of the cells in the dorsal tergite showed no broad reexpression, indicating that ry is upstream of broad in the JH signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.