ArticleGenetics2008
Examination of interchromosomal interactions in vegetatively growing diploid Schizosaccharomyces pombe cells by Cre/loxP site-specific recombination.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- GrapHi-C: graph-based visualization of Hi-C datasets.BMC research notes · 2018Article
- The biology and polymer physics underlying large-scale chromosome organization.Traffic (Copenhagen, Denmark) · 2018Review
- Recombination-independent recognition of DNA homology for repeat-induced point mutation.Current genetics · 2017Review
- A streamlined tethered chromosome conformation capture protocol.BMC genomics · 2016Article
- Chromosome domain architecture and dynamic organization of the fission yeast genome.FEBS letters · 2015Review
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- Recombination, Pairing, and Synapsis of Homologs during Meiosis.Cold Spring Harbor perspectives in biology · 2015Review
- Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe.Nature · 2014Article
- Localization of rRNA genes in the nuclear space of Calliphora erythrocephala Mg. nurse cells during polytenization.Protoplasma · 2014Article
- Subnuclear relocalization and silencing of a chromosomal region by an ectopic ribosomal DNA repeat.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Dynamic trans interactions in yeast chromosomes.PloS one · 2013Article
- Multiple opposing constraints govern chromosome interactions during meiosis.PLoS genetics · 2013Article
- Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery.Developmental cell · 2012Article
- Generation and analysis of a barcode-tagged insertion mutant library in the fission yeast Schizosaccharomyces pombe.BMC genomics · 2012Article
- Signatures of DNA flexibility, interactions and sequence-related structural variations in classical X-ray diffraction patterns.Nucleic acids research · 2011Article
- Electrostatic braiding and homologous pairing of DNA double helices.Biophysical journal · 2011Article
- Chromosome territories.Cold Spring Harbor perspectives in biology · 2010Review
- Single molecule detection of direct, homologous, DNA/DNA pairing.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Transcriptional regulation at the yeast nuclear envelope.Nucleus (Austin, Tex.)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The probability with which different regions of a genome come in contact with one another is a question of general interest. The current study addresses this subject for vegetatively growing diploid cells of fission yeast Schizosaccharomyces pombe by application of the Cre/loxP site-specific recombination assay. High levels of allelic interactions imply a tendency for chromosomes to be colocalized along their lengths. Significant homology-dependent pairing at telomere proximal loci and robust nonspecific clustering of centromeres appear to be the primary determinants of this feature. Preference for direct homolog-directed interactions at interstitial chromosomal regions was ambiguous, perhaps as a consequence of chromosome flexibility and the constraints and dynamic nature of the nucleus. Additional features of the data provide evidence for chromosome territories and reveal an intriguing phenomenon in which interaction frequencies are favored for nonhomologous loci that are located at corresponding relative (rather than absolute) positions within their respective chromosome arms. The latter feature, and others, can be understood as manifestations of transient, variable, and/or occasional nonspecific telomeric associations. We discuss the factors whose interplay sets the probabilities of chromosomal interactions in this organism and implications of the inferred organization for ectopic recombination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.