Evidence map›Paper›PMID 18202320›Full record

Trial reportArteriosclerosis, thrombosis, and vascular biology2008

Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1.

Chih-Ching Lin, Xiao-Ming Liu, Kelly Peyton, Hong Wang, Wu-Chang Yang, Shing-Jong Lin, William Durante

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04011072 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Far Infrared Therapy on Arteriovenous Fistulas Maturation, Survival and Stenosis. A Randomized, Controlled Open-labeled Multicenter Study

TypeinterventionalSponsorHerlev and Gentofte HospitalRan2019 to 2023Enrolled206ConditionsArterio-venous FistulaArmsFar infrared radiation
NCT04344067 phase3unknown statusnot on this mapstarted 2016, after this paper: background citation

The Effect of Far Infrared Therapy on Peritoneal Function of CAPD Patients

TypeinterventionalSponsorTaipei Veterans General Hospital, TaiwanRan2016 to 2020Enrolled100ConditionsEnd-stage Renal DiseaseArmsFar Infrared Therapy
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Chih-Ching LinInstitute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Xiao-Ming Liu
Kelly Peyton
Hong Wang
Wu-Chang Yang
Shing-Jong Lin
William Durante
Temple University · USNational Yang Ming Chiao Tung University · TWNational Yang Ming University Hospital · TWTaipei Veterans General Hospital · TW

Funding

CARBON MONOXIDE AND VASCULAR SMOOTH MUSCLE CELL FUNCTIONR01HL059976 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DURANTE, WILLIAM · 1999 to 2013
$3.3M
ARGINASE AND ARTERIAL INJURYR01HL074966 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DURANTE, WILLIAM · 2005 to 2009
$1.6M
VASCULAR CELL CATIONIC AMINO ACID TRANSPORT &METABOLISMR01HL062467 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI SCHAFER, ANDREW I · 1999 to 2002
$926k
NHLBI NIH HHS R01 HL059976NHLBI NIH HHS R01 HL074966NHLBI NIH HHS R01 HL59976NHLBI NIH HHS R01 HL62467NHLBI NIH HHS R01 HL74966
6 · The paper itself

Abstract

objectiveSurvival of arteriovenous fistulas (AVFs) in hemodialysis patients is associated with both far infrared (FIR) therapy and length polymorphisms of the heme oxygenase-1 (HO-1) promoter. In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation. METHODS AND

resultsTreatment of cultured human umbilical vein endothelial cells (ECs) with FIR radiation stimulated HO-1 protein, mRNA, and promoter activity. HO-1 induction was dependent on the activation of the antioxidant responsive element/NF-E2-related factor-2 complex, and was likely a consequence of heat stress. FIR radiation also inhibited tumor necrosis factor (TNF)-alpha-mediated expression of E-selectin, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-8, and the cytokine-mediated adhesion of monocytes to ECs. The antiinflammatory action of FIR was mimicked by bilirubin, and was reversed by the HO inhibitor, tin protoporphyrin-IX, or by the selective knockdown of HO-1. Finally, the antiinflammatory effect of FIR was also observed in patients undergoing hemodialysis.

conclusionsThese results demonstrate that FIR therapy exerts a potent antiinflammatory effect via the induction of HO-1. The ability of FIR therapy to inhibit inflammation may play a critical role in preserving blood flow and patency of AVFs in hemodialysis patients.

Indexed as

AgedCells, CulturedEndothelial CellsEndothelium, VascularEnzyme InductionFemaleGene ExpressionHeme Oxygenase-1HumansInflammationInflammation MediatorsInfrared RaysIntercellular Adhesion Molecule-1MaleMiddle AgedMutationHeme Oxygenase-1Inflammation MediatorsIntercellular Adhesion Molecule-1NFE2L2 protein, humanNF-E2-Related Factor 2RNA, MessengerTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID18202320
PMCPMC2748062
OpenAlexW2147468047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.