ArticleJournal of applied physiology (Bethesda, Md. : 1985)2008
Skeletal muscle contractile protein function is preserved in human heart failure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Calcium ATPase (PMCA) and GLUT-4 Upregulation in the Transverse Tubule Membrane of Skeletal Muscle from a Rat Model of Chronic Heart Failure.International journal of molecular sciences · 2024Article
- Heart Failure-Induced Skeletal Muscle Wasting.Current heart failure reports · 2020Review
- Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.Skeletal muscle · 2019Article
- Skeletal Muscle Changes in Chronic Cardiac Disease and Failure.Comprehensive Physiology · 2015Review
- Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.Frontiers in physiology · 2014Review
- Metabolic and structural impairment of skeletal muscle in heart failure.Heart failure reviews · 2013Review
- Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function.PloS one · 2013Article
- Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humans.The Journal of physiology · 2010Article
- The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.Circulation. Heart failure · 2009Article
- Comparison of skeletal muscle strength between cardiac patients and age-matched healthy controls.International journal of medical sciences · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Skeletal muscle weakness is a common finding in patients with chronic heart failure (CHF). This functional deficit cannot be accounted for by muscle atrophy alone, suggesting that the syndrome of heart failure induces a myopathy in the skeletal musculature. To determine whether decrements in muscle performance are related to alterations in contractile protein function, biopsies were obtained from the vastus lateralis muscle of four CHF patients and four control patients. CHF patients exhibited reduced peak aerobic capacity and knee extensor muscle strength. Decrements in whole muscle strength persisted after statistical control for muscle size. Thin filaments and myosin were isolated from biopsies and mechanically assessed using the in vitro motility assay. Isolated skeletal muscle thin-filament function, however, did not differ between CHF patients and controls with respect to unloaded shortening velocity, calcium sensitivity, or maximal force. Similarly, no difference in maximal force or unloaded shortening velocity of isolated myosin was observed between CHF patients and controls. From these results, we conclude that skeletal contractile protein function is unaltered in CHF patients. Other factors, such as a decrease in total muscle myosin content, are likely contributors to the skeletal muscle strength deficit of heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.