ArticleThe Journal of physiology2008
Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Motion as Medicine: Physical Activity, Joint Sensitivity, and Pain Management-A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Thick or Thin? Implications of Cartilage Architecture for Osteoarthritis Risk in Sedentary Lifestyles.Biomedicines · 2025Review
- Rethinking Osteoarthritis Management: Synergistic Effects of Chronoexercise, Circadian Rhythm, and Chondroprotective Agents.Biomedicines · 2025Article
- Mechanobiology of Hyaluronan: Connecting Biomechanics and Bioactivity in Musculoskeletal Tissues.Annual review of biomedical engineering · 2024Review
- Clinical and Biochemical Implications of Hyaluronic Acid in Musculoskeletal Rehabilitation: A Comprehensive Review.Journal of personalized medicine · 2023Review
- The Role of Lubricin, Irisin and Exercise in the Prevention and Treatment of Osteoarthritis.International journal of molecular sciences · 2023Review
- Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear.Journal of biomechanics · 2023Article
- Tensile strain and altered synovial tissue metabolism in human knee osteoarthritis.Scientific reports · 2022Article
- Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis.Channels (Austin, Tex.) · 2021Review
- Attachment of cartilage wear particles to the synovium negatively impacts friction properties.Journal of biomechanics · 2021Article
- Mechanical adaptation of synoviocytes A and B to immobilization and remobilization: a study in the rat knee flexion model.Journal of molecular histology · 2020Article
- Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key.International journal of molecular sciences · 2019Article
- Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.The Journal of physiology · 2017Review
- Mechanotransduction and cartilage integrity.Annals of the New York Academy of Sciences · 2011Review
- Fluid movement and joint capsule strains due to flexion in rabbit knees.Journal of biomechanics · 2011Article
- Ionic currents in intimal cultured synoviocytes from the rabbit.American journal of physiology. Cell physiology · 2010Article
- Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release.Annals of the rheumatic diseases · 2010Article
- Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits.The Journal of physiology · 2009Article
- Bend those knees!The Journal of physiology · 2008Article
- A systems biology approach to synovial joint lubrication in health, injury, and disease.Wiley interdisciplinary reviews. Systems biology and medicineReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The novel hypothesis that the secretion of the joint lubricant hyaluronan (HA) is coupled to movement has implications for normal function and osteoarthritis, and was tested in the knee joints of anaesthetized rabbits. After washing out the endogenous synovial fluid HA (miscibility coefficient 0.4), secretion into the joint cavity was measured over 5 h in static joints and in passively cycled joints. The net static secretion rate (11.2 +/- 0.7 microg h(-1), mean +/- s.e.m., n = 90) correlated with the variable endogenous HA mass (mean 367 +/- 8 microg), with a normalized value of 3.4 +/- 0.2 microg h(-1) (100 microg)(-1) . Cyclic joint movement approximately doubled the net HA secretion rate to 22.6 +/- 1.2 microg h(-1) (n = 77) and raised the normalized percentage to 5.9 +/- 0.3 microg h(-1) (100 microg)(-1). Secretion was inhibited by 2-deoxyglucose and iodoacetate, confirming active secretion. The net accumulation rate underestimated true secretion rate due to some trans-synovial loss. HA turnover time (endogenous mass/secretion rate) was 17-30 h (static) to 8-15 h (moved) The results demonstrate for the first time that the active secretion of HA is coupled to joint usage. Movement-secretion coupling may protect joints against the damaging effects of repetitive joint use, replace HA lost during periods of immobility (overnight), and contribute to the clinical benefit of exercise therapy in moderate osteoarthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.