ArticlePhysical therapy2008
Dose estimation and surveillance of mechanical loading interventions for bone loss after spinal cord injury.
Article in Physical therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Musculoskeletal Plasticity After Spinal Cord Injury
Long Duration Activity and Metabolic Control After Spinal Cord Injury
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Evidence-based prevention and treatment of osteoporosis after spinal cord injury: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Pooled it
- Effects of electromyostimulation on muscle and bone in men with acute traumatic spinal cord injury: A randomized clinical trial.The journal of spinal cord medicine · 2014Trial
- Active-resisted stance modulates regional bone mineral density in humans with spinal cord injury.The journal of spinal cord medicine · 2013Trial
- Mechanical interplay between adipose tissues and disease progression.Bioengineering & translational medicine · 2026Review
- Prevention and management of osteoporosis and osteoporotic fractures in persons with a spinal cord injury or disorder: A systematic scoping review.The journal of spinal cord medicine · 2019Article
- Novel instrumented frame for standing exercising of users with complete spinal cord injuries.Scientific reports · 2019Article
- Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?Cell death and differentiation · 2016Review
- Characterization of unexpected postural changes during robot-assisted gait training in paraplegic patients.Spinal cord · 2016Article
- The bone-fat interface: basic and clinical implications of marrow adiposity.The lancet. Diabetes & endocrinology · 2015Review
- Limb compressive load does not inhibit post activation depression of soleus H-reflex in indiviudals with chronic spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013Article
- Time-course response in serum markers of bone turnover to a single-bout of electrical stimulation in patients with recent spinal cord injury.European journal of applied physiology · 2013Article
- High dose compressive loads attenuate bone mineral loss in humans with spinal cord injury.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Limb segment load inhibits post activation depression of soleus H-reflex in humans.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2012Article
- A biomechanical analysis of exercise in standing, supine, and seated positions: Implications for individuals with spinal cord injury.The journal of spinal cord medicine · 2012Article
- Regional cortical and trabecular bone loss after spinal cord injury.Journal of rehabilitation research and development · 2012Article
- Gravitational force modulates muscle activity during mechanical oscillation of the tibia in humans.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2011Article
- Enhancing muscle force and femur compressive loads via feedback-controlled stimulation of paralyzed quadriceps in humans.Archives of physical medicine and rehabilitation · 2011Article
- Reliability and responsiveness of musculoskeletal ultrasound in subjects with and without spinal cord injury.Ultrasound in medicine & biology · 2010Article
- Longitudinal changes in femur bone mineral density after spinal cord injury: effects of slice placement and peel method.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Fatigue and non-fatigue mathematical muscle models during functional electrical stimulation of paralyzed muscle.Biomedical signal processing and control · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe interpretation of the results of previous anti-osteoporosis interventions after spinal cord injury (SCI) is undermined by incomplete information about the intervention dose or patient adherence to dose requirements. Rehabilitation research as a whole traditionally has struggled with these same issues. The purpose of this case report is to offer proof of the concepts that careful dose selection and surveillance of patient adherence should be integral components in rehabilitation interventions. CASE DESCRIPTION: A 21-year-old man with T4 complete paraplegia (7 weeks) enrolled in a unilateral soleus muscle electrical stimulation protocol. Compressive loads applied to the tibia approximated 1.4 times body weight. Over 4.8 years of home-based training, data logging software provided surveillance of adherence. Soleus muscle torque and fatigue index adaptations to training as well as bone mineral density (BMD) adaptations in the distal tibia were measured. OUTCOMES: The patient performed nearly 8,000 soleus muscle contractions per month, with occasional fluctuations. Adherence tracking permitted intervention when adherence fell below acceptable values. The soleus muscle torque and fatigue index increased rapidly in response to training. The BMD of the untrained tibia declined approximately 14% per year. The BMD of the trained tibia declined only approximately 7% per year. The BMD was preferentially preserved in the posterior half of the tibia; this region experienced only a 2.6% annual decline. DISCUSSION: Early administration of a load intervention, careful estimation of the loading dose, and detailed surveillance of patient adherence aided in the interpretation of a patient's adaptations to a mechanical load protocol. These concepts possess wider applicability to rehabilitation research and should be emphasized in future physical therapy investigations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.