Evidence map›Paper›PMID 18201781›Full record

ArticleInternational journal of cardiology2009

Changing trends (1986-2003) in the use of lipid lowering medication in patients hospitalized with acute myocardial infarction: a community-based perspective.

Jorge Yarzebski, Edgard Granillo, Frederick A Spencer, Darleen Lessard, Jerry H Gurwitz, Joel M Gore, Robert J Goldberg

Abstract read
In one paragraph

Article in International journal of cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jorge YarzebskiDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Edgard Granillo
Frederick A Spencer
Darleen Lessard
Jerry H Gurwitz
Joel M Gore
Robert J Goldberg
University of Massachusetts Chan Medical School · USBrown University · USMcMaster University Medical Centre · CA

Funding

WORCHESTER HEART ATTACK COMMUNITY SURVEILLANCE STUDYR01HL035434 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOLDBERG, ROBERT JOEL · 1987 to 2014
$7.4M
PHYSICIAN AND PATIENT ATTITUDES TOWARD CHOLESTEROLK01HL004047 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI YARZEBSKI, JORGE L · 1999 to 2003
$515k
NHLBI NIH HHS K01 HL004047NHLBI NIH HHS KO1-HL-04047NHLBI NIH HHS R01 HL035434NHLBI NIH HHS R01 HL35434
6 · The paper itself

Abstract

objectivesThe objectives of this community-wide observational study were to describe nearly two decade long (1986-2003) trends in the use of lipid lowering therapy in patients hospitalized with acute myocardial infarction (AMI) and clinical and demographic factors associated with underutilization of this treatment regimen.

methodsA total of 9429 greater Worcester (MA) residents hospitalized with confirmed AMI at all metropolitan Worcester medical centers in 10 annual periods between 1986 and 2003 comprised the study population. Hospital medical records were reviewed to ascertain the prescribing of lipid lowering agents during hospitalization for AMI.

resultsThe mean age of the study sample was 70 years, 58% were men, and the average total and LDL serum cholesterol levels were 203 and 114 mg/dL, respectively. There was a marked increase in the use of lipid lowering therapy in greater Worcester residents hospitalized with AMI between 1986 (<1%) and 2003 (76%). Increasing use of lipid lowering medication was observed both with regards to the maintenance of this therapy in patients who were already on this treatment regimen and in the new initiation of lipid lowering medication in patients who had not been previously treated with this therapy. Several patient demographic and clinical factors, including advanced age and an initial AMI, were associated with the failure to be prescribed lipid lowering therapy during hospitalization for AMI.

conclusionsThe results of this study suggest encouraging increases over time in the use of lipid lowering therapy in patients hospitalized with AMI. Despite these encouraging trends, several high-risk patient groups remain suboptimally treated.

Indexed as

AgedAnticholesteremic AgentsConfidence IntervalsDrug UtilizationFemaleHospitals, CommunityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPractice Patterns, Physicians'Residence CharacteristicsRetrospective StudiesRisk FactorsAnticholesteremic Agents

Identifiers

PMID18201781
PMCPMC4569868
OpenAlexW2087693041

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.