ArticleDevelopmental biology2008
Enabled (Xena) regulates neural plate morphogenesis, apical constriction, and cellular adhesion required for neural tube closure in Xenopus.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Vinculin is required for interkinetic nuclear migration (INM) and cell cycle progression.The Journal of cell biology · 2024Article
- The mechanical forces that shape our senses.Development (Cambridge, England) · 2022Review
- The lens actin filament cytoskeleton: Diverse structures for complex functions.Experimental eye research · 2017Review
- Mechanics of neurulation: From classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube.Birth defects research · 2017Review
- MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation.Developmental biology · 2015Article
- Epithelial morphogenesis: the mouse eye as a model system.Current topics in developmental biology · 2015Review
- p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.Development (Cambridge, England) · 2014Article
- The continuing challenge of understanding, preventing, and treating neural tube defects.Science (New York, N.Y.) · 2013Review
- Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis.Cell research · 2013Article
- Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate.Molecular biology of the cell · 2011Article
- Apical constriction: a cell shape change that can drive morphogenesis.Developmental biology · 2010Review
- Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.Development (Cambridge, England) · 2010Article
- The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.Developmental biology · 2009Article
- Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.Developmental biology · 2009Article
- A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation.Journal of cell science · 2009Article
- N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements.Development (Cambridge, England) · 2009Article
- Totally tubular: the mystery behind function and origin of the brain ventricular system.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of cellular adhesion and cytoskeletal dynamics is essential for neurulation, though it remains unclear how these two processes are coordinated. Members of the Ena/VASP family of proteins are localized to sites of cellular adhesion and actin dynamics and lack of two family members, Mena and VASP, in mice results in failure of neural tube closure. The precise mechanism by which Ena/VASP proteins regulate this process, however, is not understood. In this report, we show that Xenopus Ena (Xena) is localized to apical adhesive junctions of neuroepithelial cells during neurulation and that Xena knockdown disrupts cell behaviors integral to neural tube closure. Changes in the shape of the neural plate as well as apical constriction within the neural plate are perturbed in Xena knockdown embryos. Additionally, we demonstrate that Xena is essential for cell-cell adhesion. These results demonstrate that Xena plays an integral role in coordinating the regulation of cytoskeletal dynamics and cellular adhesion during neurulation in Xenopus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.