ArticleWorld journal of gastroenterology2008
Effect of Daxx on cholesterol accumulation in hepatic cells.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Review
- Association between metabolic dysfunction-associated fatty liver disease and risk of incidence of gallstones, evidence from a 5-year railway safety staff retrospective cohort study.Frontiers in medicine · 2025Article
- Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition.Acta pharmacologica Sinica · 2011Article
- A novel model of cholesterol efflux from lipid-loaded cells.Acta pharmacologica Sinica · 2010Review
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effect of Daxx on cholesterol accumulation in hepatic cells.
methodsSprague Dawley (SD) rats were fed a normal or high fat diet for 6 wk, and serum lipids and Daxx expression of hepatic tissues were measured by immunoblot assays. HepG(2) cells were transfected with the pEGFP-C1/Daxx or pEGFP-C1 plasmid. Cells stably transfected with Daxx were identified by RT-PCR analysis. Total cholesterol levels were determined by high performance liquid chromatography. Activated-SREBP and caveolin-1 were assayed by western blotting.
resultsHepatic Daxx protein was higher in normal rats than in high fat diet-fed rats. Noticeable negative correlations were seen between Daxx and LDL-C (gamma = -7.56, P = 0.018), and between Daxx and TC (gamma = -9.07, P = 0.01), respectively. The total cholesterol of HepG(2)/GFP-Daxx cells was lower than that of control cells or HepG(2)/GFP cells (9.28 +/- 0.19 vs 14.36 +/- 4.45 or 13.94 +/- 2.62, both P < 0.05). Furthermore, in HepG(2)/GFP cells, the expression of activated SREBP was lower than that of control cells, whereas caveolin-1 expression was higher.
conclusionOverexpression of Daxx in HepG(2) cells decreased intracellular cholesterol accumulation, which might be associated with inhibition of SREBP activity and an increase in caveolin-1 expression.
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